Seroatlas · Human Serome Atlas

PHLDB3

Pleckstrin homology-like domain family B member 3

Also known as: FLJ40193, PHLB3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NSJ2
Gene: PHLDB3
Ensembl: ENSG00000176531
Chromosome: 19
Canonical length: 640 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables enzyme binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

640 residues, UniProt reviewed canonical sequence.

>Q6NSJ2|PHLDB3
     1  MGTRSSPEEG TPPPLVPECD VEVQPQGHPE ESREQEASEV LAEPSSRGGA EQQAEEEEVG
    61  EGSSTESSRD APEATPPIAM AATPPASTSS REGVRGAARR LQGQQLEALT RVALMEQRVK
   121  ELQRQRKELR IEMEVEVALL RGELAGERVA ARREEEQLRE LLEQQAASEQ RGRQQREQEQ
   181  RRLSQERDRL EGLRQRLRKA QGQLDSQPED QRERLLQGVQ EMREQLDVAQ RAYEDLEFQQ
   241  LERESRQEEE DRDSPGPQVP DPKVQELQAS MAQHRRGALQ HRIRVLEEQL KSLGEQMAAE
   301  SRGLSRKKEE ALQALSQERS RLLELNCLQG TPGGDFSEPN PALTKLLFTQ KTDRQLLVLQ
   361  DAVAHSAATP TSSCLFSVHS SLQGSIGLQR TGSLPRKRGE RGSQRGSPRP LSFHCTESLE
   421  ASALPPAVGD SGRYPLYQLL NCGRGNSCGA IHPDIAHMER LLQQAMAERE RLLKAREGTR
   481  RGTEGSSGPA VPAITAPPTP PHPPGPRILD LRQHLEGWGH NPENCPHVQV SGCCCRGPLV
   541  KMGGRIKTWR KRWFCFDRQA RRLAYYADKE ETKLKGVIYF QAIEEVYYDH LRCAFKSPNP
   601  RLTFCVKTYE RLFYMVAPSP EAMRIWMDVI VTAADENHAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PHLDB3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

skin: 44 nTPM
esophagus: 43 nTPM
testis: 30 nTPM
vagina: 23 nTPM
cervix: 19 nTPM
salivary gland: 16 nTPM

Single-cell type

esophageal apical cells: 596 nCPM
esophageal suprabasal cells: 151 nCPM
syncytiotrophoblasts: 116 nCPM
suprabasal keratinocytes: 114 nCPM
urothelial cells: 100 nCPM
ocular epithelial cells: 99 nCPM

Immune cell

plasmacytoid DC: 5.5 nTPM
myeloid DC: 4.6 nTPM
naive CD4 T-cell: 3.3 nTPM
naive CD8 T-cell: 3.1 nTPM
naive B-cell: 2.6 nTPM
gdT-cell: 2.5 nTPM

Brain region

white matter: 26 nTPM
choroid plexus: 24 nTPM
hypothalamus: 21 nTPM
cerebral cortex: 19 nTPM
amygdala: 18 nTPM
pons: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
gnomAD missense Z: -0.4
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

enzyme binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PHLDB3 as an antibody target. Whether an autoantibody or antibody against PHLDB3 could matter depends on whether native PHLDB3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PHLDB3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PHLDB3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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