PHKG1

Protein identityUniProt · HPA

UniProt accession

Q16816

Gene

PHKG1

Ensembl

ENSG00000164776

Chromosome

7

Canonical length

387 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene is a member of the Ser/Thr protein kinase family and encodes a protein with one protein kinase domain and two calmodulin-binding domains. This protein is the catalytic member of a 16 subunit protein kinase complex which contains equimolar ratios of 4 subunit types. The complex is a crucial glycogenolytic regulatory enzyme. This gene has two pseudogenes at chromosome 7q11.21 and one at chromosome 11p11.12. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

387 residues, UniProt reviewed canonical sequence.

>Q16816|PHKG1
     1  MTRDEALPDS HSAQDFYENY EPKEILGRGV SSVVRRCIHK PTSQEYAVKV IDVTGGGSFS
    61  PEEVRELREA TLKEVDILRK VSGHPNIIQL KDTYETNTFF FLVFDLMKRG ELFDYLTEKV
   121  TLSEKETRKI MRALLEVICT LHKLNIVHRD LKPENILLDD NMNIKLTDFG FSCQLEPGER
   181  LREVCGTPSY LAPEIIECSM NEDHPGYGKE VDMWSTGVIM YTLLAGSPPF WHRKQMLMLR
   241  MIMSGNYQFG SPEWDDYSDT VKDLVSRFLV VQPQNRYTAE EALAHPFFQQ YLVEEVRHFS
   301  PRGKFKVIAL TVLASVRIYY QYRRVKPVTR EIVIRDPYAL RPLRRLIDAY AFRIYGHWVK
   361  KGQQQNRAAL FENTPKAVLL SLAEEDY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PHKG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

273 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.25

gnomAD pLI

0

gnomAD missense Z

0.59

DepMap mean gene effect

-0.1

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• carbohydrate metabolic process
• glycogen catabolic process
• glycogen metabolic process
• signal transduction

Molecular functions

• ATP binding
• calmodulin binding
• enzyme binding
• phosphorylase kinase activity
• protein serine kinase activity
• tau-protein kinase activity

Cellular components

• cytoplasm
• cytosol
• phosphorylase kinase complex

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Phosphorylase kinase, gamma catalytic subunit
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• Protein kinase, ATP binding site
• Protein kinase domain

KeywordsUniProt

• ATP-binding
• Calmodulin-binding
• Carbohydrate metabolism
• Glycogen metabolism
• Kinase
• Muscle protein
• Nucleotide-binding
• Serine/threonine-protein kinase
• Transferase