Seroatlas · Human Serome Atlas

PHF23

PHD finger protein 23

Also known as: FLJ16355, MGC2941, PHF23_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BUL5
Gene: PHF23
Ensembl: ENSG00000040633
Chromosome: 17
Canonical length: 403 aa
Protein class: Disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Involved in negative regulation of autophagosome assembly; negative regulation of autophagosome maturation; and positive regulation of protein ubiquitination. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

403 residues, UniProt reviewed canonical sequence.

>Q9BUL5|PHF23
     1  MLEAMAEPSP EDPPPTLKPE TQPPEKRRRT IEDFNKFCSF VLAYAGYIPP SKEESDWPAS
    61  GSSSPLRGES AADSDGWDSA PSDLRTIQTF VKKAKSSKRR AAQAGPTQPG PPRSTFSRLQ
   121  APDSATLLEK MKLKDSLFDL DGPKVASPLS PTSLTHTSRP PAALTPVPLS QGDLSHPPRK
   181  KDRKNRKLGP GAGAGFGVLR RPRPTPGDGE KRSRIKKSKK RKLKKAERGD RLPPPGPPQA
   241  PPSDTDSEEE EEEEEEEEEE EMATVVGGEA PVPVLPTPPE APRPPATVHP EGVPPADSES
   301  KEVGSTETSQ DGDASSSEGE MRVMDEDIMV ESGDDSWDLI TCYCRKPFAG RPMIECSLCG
   361  TWIHLSCAKI KKTNVPDFFY CQKCKELRPE ARRLGGPPKS GEP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PHF23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 37 nTPM
thymus: 34 nTPM
esophagus: 34 nTPM
tonsil: 32 nTPM
lymph node: 29 nTPM
urinary bladder: 27 nTPM

Single-cell type

esophageal apical cells: 192 nCPM
syncytiotrophoblasts: 94 nCPM
esophageal suprabasal cells: 64 nCPM
suprabasal keratinocytes: 62 nCPM
basal keratinocytes: 62 nCPM
breast hormone-responsive cells: 54 nCPM

Immune cell

basophil: 23 nTPM
memory CD8 T-cell: 18 nTPM
plasmacytoid DC: 17 nTPM
gdT-cell: 16 nTPM
neutrophil: 16 nTPM
naive B-cell: 16 nTPM

Brain region

midbrain: 53 nTPM
medulla oblongata: 42 nTPM
pons: 42 nTPM
cerebral cortex: 40 nTPM
thalamus: 38 nTPM
hypothalamus: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.17
gnomAD pLI: 1
gnomAD missense Z: 0.96
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

zinc ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PHF23 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

LRSAM1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PHF23 as an antibody target. Whether an autoantibody or antibody against PHF23 could matter depends on whether native PHF23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PHF23 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PHF23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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