Seroatlas · Human Serome Atlas

PGS1

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

Also known as: DKFZP762M186, PGPS1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q32NB8
Gene
PGS1
Ensembl
ENSG00000087157
Chromosome
17
Canonical length
556 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Vesicles,Plasma membrane,Cell Junctions,Mid piece

OverviewNCBI Gene

Predicted to enable CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity and calcium ion binding activity. Predicted to be involved in cardiolipin biosynthetic process and diacylglycerol metabolic process. Located in endoplasmic reticulum. Is active in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

556 residues, UniProt reviewed canonical sequence.

>Q32NB8|PGS1
     1  MAVAAAAAAG PVFWRRLLGL LPGRPGLAAL LGRLSDRLGR NRDRQRRRSP WLLLAPLLSP
    61  AVPQVTSPPC CLCPEGVHRF QWIRNLVPEF GVSSSHVRVL SSPAEFFELM KGQIRVAKRR
   121  VVMASLYLGT GPLEQELVDC LESTLEKSLQ AKFPSNLKVS ILLDFTRGSR GRKNSRTMLL
   181  PLLRRFPEQV RVSLFHTPHL RGLLRLLIPE RFNETIGLQH IKVYLFDNSV ILSGANLSDS
   241  YFTNRQDRYV FLQDCAEIAD FFTELVDAVG DVSLQLQGDD TVQVVDGMVH PYKGDRAEYC
   301  KAANKRVMDV INSARTRQQM LHAQTFHSNS LLTQEDAAAA GDRRPAPDTW IYPLIQMKPF
   361  EIQIDEIVTE TLLTEAERGA KVYLTTGYFN LTQAYMDLVL GTRAEYQILL ASPEVNGFFG
   421  AKGVAGAIPA AYVHIERQFF SEVCSLGQQE RVQLQEYWRR GWTFHAKGLW LYLAGSSLPC
   481  LTLIGSPNFG YRSVHRDLEA QIAIVTENQA LQQQLHQEQE QLYLRSGVVS SATFEQPSRQ
   541  VKLWVKMVTP LIKNFF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PGS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 37 nTPM
  • lung: 27 nTPM
  • spleen: 24 nTPM
  • placenta: 19 nTPM
  • thyroid gland: 18 nTPM
  • adipose tissue: 17 nTPM

Single-cell type

  • neutrophils: 869 nCPM
  • neutrophil progenitors: 155 nCPM
  • monocytes: 154 nCPM
  • alveolar cells type 2: 60 nCPM
  • vascular endothelial cells: 60 nCPM
  • monocyte progenitors: 57 nCPM

Immune cell

  • neutrophil: 34 nTPM
  • myeloid DC: 21 nTPM
  • eosinophil: 19 nTPM
  • classical monocyte: 18 nTPM
  • T-reg: 15 nTPM
  • intermediate monocyte: 15 nTPM

Brain region

  • cerebral cortex: 55 nTPM
  • thalamus: 41 nTPM
  • medulla oblongata: 38 nTPM
  • white matter: 37 nTPM
  • hypothalamus: 35 nTPM
  • choroid plexus: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.13
gnomAD pLI
0
gnomAD missense Z
1.5
DepMap mean gene effect
-0.58
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PGS1 as an antibody target. Whether an autoantibody or antibody against PGS1 could matter depends on whether native PGS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PGS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PGS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PGS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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