Seroatlas · Human Serome Atlas

PGPEP1L

Pyroglutamyl-peptidase 1-like protein

Also known as: PGPIL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NFU8
Gene: PGPEP1L
Ensembl: ENSG00000183571
Chromosome: 15
Canonical length: 196 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol,Equatorial segment

OverviewNCBI Gene

Predicted to enable pyroglutamyl-peptidase activity. Predicted to be involved in proteolysis. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

196 residues, UniProt reviewed canonical sequence.

>A6NFU8|PGPEP1L
     1  MKPRTLVELS KLGLGNETVV QLRTLELPVD YREAKRRVTG IWEDHQPQLV VHVGMDTAAK
    61  AIILEQSGKN QGYRDADIRS FWPEGGVCLP GSPDVLESGV CMKAVCKRVA VEGVDVIFSR
   121  DAGRYVCDYT YYLSLHHGKG CAALIHVPPL SRGLPASLLG RALRVIIQEM LEEVGKPKHR
   181  AQFEENSTMV LPAKGN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PGPEP1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 29 nTPM
tongue: 6.9 nTPM
heart muscle: 3.6 nTPM
blood vessel: 2.2 nTPM
testis: 2 nTPM
esophagus: 0.8 nTPM

Single-cell type

myonuclei: 0.8 nCPM
thymocytes: 0.8 nCPM
early spermatids: 0.3 nCPM
late primary spermatocytes: 0.3 nCPM
peritubular myoid cells: 0.3 nCPM
early primary spermatocytes: 0.2 nCPM

Immune cell

basophil: 0.3 nTPM
neutrophil: 0.3 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 4.2 nTPM
white matter: 3.9 nTPM
basal ganglia: 3.5 nTPM
amygdala: 3.1 nTPM
hypothalamus: 2.9 nTPM
midbrain: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.95
gnomAD pLI: 0
gnomAD missense Z: -1.09
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

cysteine-type peptidase activity

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PGPEP1L as an antibody target. Whether an autoantibody or antibody against PGPEP1L could matter depends on whether native PGPEP1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PGPEP1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PGPEP1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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