PGPEP1

Protein identityUniProt · HPA

UniProt accession

Q9NXJ5

Gene

PGPEP1

Ensembl

ENSG00000130517

Chromosome

19

Canonical length

209 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Golgi apparatus

OverviewNCBI Gene

The gene encodes a cysteine protease and member of the peptidase C15 family of proteins. The encoded protein cleaves amino terminal pyroglutamate residues from protein substrates including thyrotropin-releasing hormone and other neuropeptides. Expression of this gene may be downregulated in colorectal cancer, while activity of the encoded protein may be negatively correlated with cancer progression in colorectal cancer patients. Activity of the encoded protease may also be altered in other disease states including in liver cirrhosis, which is associated with reduced protease activity, and in necrozoospermia, which is associated with elevated protease activity. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

209 residues, UniProt reviewed canonical sequence.

>Q9NXJ5|PGPEP1
     1  MEQPRKAVVV TGFGPFGEHT VNASWIAVQE LEKLGLGDSV DLHVYEIPVE YQTVQRLIPA
    61  LWEKHSPQLV VHVGVSGMAT TVTLEKCGHN KGYKGLDNCR FCPGSQCCVE DGPESIDSII
   121  DMDAVCKRVT TLGLDVSVTI SQDAGRYLCD FTYYTSLYQS HGRSAFVHVP PLGKPYNADQ
   181  LGRALRAIIE EMLDLLEQSE GKINYCHKH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PGPEP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

47 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.95

gnomAD pLI

0.01

gnomAD missense Z

0.35

DepMap mean gene effect

-0.17

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• protein catabolic process
• proteolysis

Molecular functions

• pyroglutamyl-peptidase activity

Cellular components

• cytosol

Protein domainsUniProt · Pfam · InterPro

• Peptidase C15, pyroglutamyl peptidase I-like
• Peptidase C15, pyroglutamyl peptidase I-like superfamily
• Pyroglutamyl peptidase
• Peptidase C15, pyroglutamyl peptidase I
• Pyroglutamyl peptidase I, Glu active site
• Pyroglutamyl peptidase I, Cys active site

KeywordsUniProt

• Cytoplasm
• Hydrolase
• Protease
• Thiol protease