Seroatlas · Human Serome Atlas

PGP

Glycerol-3-phosphate phosphatase

Also known as: PGP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NDG6
Gene: PGP
Ensembl: ENSG00000184207
Chromosome: 16
Canonical length: 321 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nuclear bodies
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables glycerol-3-phosphatase activity and phosphoglycolate phosphatase activity. Involved in glycerol biosynthetic process; glycerophospholipid metabolic process; and negative regulation of gluconeogenesis. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

321 residues, UniProt reviewed canonical sequence.

>A6NDG6|PGP
     1  MAAAEAGGDD ARCVRLSAER AQALLADVDT LLFDCDGVLW RGETAVPGAP EALRALRARG
    61  KRLGFITNNS SKTRAAYAEK LRRLGFGGPA GPGASLEVFG TAYCTALYLR QRLAGAPAPK
   121  AYVLGSPALA AELEAVGVAS VGVGPEPLQG EGPGDWLHAP LEPDVRAVVV GFDPHFSYMK
   181  LTKALRYLQQ PGCLLVGTNM DNRLPLENGR FIAGTGCLVR AVEMAAQRQA DIIGKPSRFI
   241  FDCVSQEYGI NPERTVMVGD RLDTDILLGA TCGLKTILTL TGVSTLGDVK NNQESDCVSK
   301  KKMVPDFYVD SIADLLPALQ G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PGP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 60 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 60 nTPM
testis: 44 nTPM
skeletal muscle: 35 nTPM
cerebral cortex: 32 nTPM
heart muscle: 28 nTPM
hippocampal formation: 19 nTPM

Single-cell type

late spermatids: 2,429 nCPM
early spermatids: 479 nCPM
late primary spermatocytes: 402 nCPM
cone photoreceptor cells: 197 nCPM
cytotrophoblasts: 151 nCPM
retinal ganglion cells: 147 nCPM

Immune cell

eosinophil: 2.5 nTPM
intermediate monocyte: 1.2 nTPM
non-classical monocyte: 1.2 nTPM
classical monocyte: 0.8 nTPM
naive B-cell: 0.8 nTPM
gdT-cell: 0.7 nTPM

Brain region

pons: 53 nTPM
cerebral cortex: 52 nTPM
cerebellum: 36 nTPM
medulla oblongata: 36 nTPM
white matter: 32 nTPM
basal ganglia: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0.16
gnomAD missense Z: 1.3
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PGP as an antibody target. Whether an autoantibody or antibody against PGP could matter depends on whether native PGP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PGP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PGP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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