Seroatlas · Human Serome Atlas

PGM3

Phosphoacetylglucosamine mutase

Also known as: AGM1, AGM1_HUMAN, DKFZP434B187, PAGM

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95394
Gene
PGM3
Ensembl
ENSG00000013375
Chromosome
6
Canonical length
542 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the phosphohexose mutase family. The encoded protein mediates both glycogen formation and utilization by catalyzing the interconversion of glucose-1-phosphate and glucose-6-phosphate. A non-synonymous single nucleotide polymorphism in this gene may play a role in resistance to diabetic nephropathy and neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

542 residues, UniProt reviewed canonical sequence.

>O95394|PGM3
     1  MDLGAITKYS ALHAKPNGLI LQYGTAGFRT KAEHLDHVMF RMGLLAVLRS KQTKSTIGVM
    61  VTASHNPEED NGVKLVDPLG EMLAPSWEEH ATCLANAEEQ DMQRVLIDIS EKEAVNLQQD
   121  AFVVIGRDTR PSSEKLSQSV IDGVTVLGGQ FHDYGLLTTP QLHYMVYCRN TGGRYGKATI
   181  EGYYQKLSKA FVELTKQASC SGDEYRSLKV DCANGIGALK LREMEHYFSQ GLSVQLFNDG
   241  SKGKLNHLCG ADFVKSHQKP PQGMEIKSNE RCCSFDGDAD RIVYYYHDAD GHFHLIDGDK
   301  IATLISSFLK ELLVEIGESL NIGVVQTAYA NGSSTRYLEE VMKVPVYCTK TGVKHLHHKA
   361  QEFDIGVYFE ANGHGTALFS TAVEMKIKQS AEQLEDKKRK AAKMLENIID LFNQAAGDAI
   421  SDMLVIEAIL ALKGLTVQQW DALYTDLPNR QLKVQVADRR VISTTDAERQ AVTPPGLQEA
   481  INDLVKKYKL SRAFVRPSGT EDVVRVYAEA DSQESADHLA HEVSLAVFQL AGGIGERPQP
   541  GF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PGM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.2
Highest tissue expression
41 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 41 nTPM
  • prostate: 35 nTPM
  • placenta: 32 nTPM
  • liver: 28 nTPM
  • pituitary gland: 22 nTPM
  • salivary gland: 21 nTPM

Single-cell type

  • pancreatic acinar cells: 162 nCPM
  • epicardial cells: 148 nCPM
  • prostatic glandular cells: 144 nCPM
  • cardiomyocytes: 138 nCPM
  • late primary spermatocytes: 131 nCPM
  • somatotrophs: 121 nCPM

Immune cell

  • basophil: 4.9 nTPM
  • memory B-cell: 2.2 nTPM
  • naive CD4 T-cell: 2.1 nTPM
  • plasmacytoid DC: 2.1 nTPM
  • naive CD8 T-cell: 2 nTPM
  • non-classical monocyte: 1.9 nTPM

Brain region

  • choroid plexus: 19 nTPM
  • cerebellum: 16 nTPM
  • white matter: 15 nTPM
  • basal ganglia: 14 nTPM
  • midbrain: 13 nTPM
  • pons: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PGM3.

Disease | AllUniProt

Conditions PGM3 is implicated in, by any mechanism.

Disease | GeneticClinVar

69 pathogenic / likely-pathogenic of 629 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.65
gnomAD pLI
0
gnomAD missense Z
1.51
DepMap mean gene effect
-0.28
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PGM3 as an antibody target. Whether an autoantibody or antibody against PGM3 could matter depends on whether native PGM3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PGM3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PGM3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PGM3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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