Seroatlas · Human Serome Atlas

PGLYRP4

Peptidoglycan recognition protein 4

Also known as: PGLYRPIbeta, PGRP-Ibeta, PGRP4_HUMAN, PGRPIB, SBBI67

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96LB8
Gene: PGLYRP4
Ensembl: ENSG00000163218
Chromosome: 1
Canonical length: 373 aa
Protein class: Metabolic proteins, Predicted secreted proteins
Subcellular location: Vesicles,Plasma membrane
Secretome location: Secreted in other tissues
Quaternary structure: Homodimer

OverviewNCBI Gene

Summary: This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]

Canonical amino-acid sequenceUniProt

373 residues, UniProt reviewed canonical sequence.

>Q96LB8|PGLYRP4
     1  MLPWLLVFSA LGIQAWGDSS WNKTQAKQVS EGLQYLFENI SQLTEKGLPT DVSTTVSRKA
    61  WGAEAVGCSI QLTTPVNVLV IHHVPGLECH DQTVCSQRLR ELQAHHVHNN SGCDVAYNFL
   121  VGDDGRVYEG VGWNIQGVHT QGYNNISLGF AFFGTKKGHS PSPAALSAME NLITYAVQKG
   181  HLSSSYVQPL LGKGENCLAP RQKTSLKKAC PGVVPRSVWG ARETHCPRMT LPAKYGIIIH
   241  TAGRTCNISD ECRLLVRDIQ SFYIDRLKSC DIGYNFLVGQ DGAIYEGVGW NVQGSSTPGY
   301  DDIALGITFM GTFTGIPPNA AALEAAQDLI QCAMVKGYLT PNYLLVGHSD VARTLSPGQA
   361  LYNIISTWPH FKH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PGLYRP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

skin: 14 nTPM
cervix: 9.9 nTPM
vagina: 9 nTPM
esophagus: 7.3 nTPM
tonsil: 1.9 nTPM
salivary gland: 1.2 nTPM

Single-cell type

esophageal apical cells: 39 nCPM
esophageal suprabasal cells: 20 nCPM
suprabasal keratinocytes: 18 nCPM
ocular epithelial cells: 8.6 nCPM
esophageal basal cells: 5.8 nCPM
salivary duct cells: 4.6 nCPM

Immune cell

neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0
gnomAD missense Z: 0
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PGLYRP4 as an antibody target. Whether an autoantibody or antibody against PGLYRP4 could matter depends on whether native PGLYRP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PGLYRP4 is annotated as secreted, so native PGLYRP4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PGLYRP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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