Seroatlas · Human Serome Atlas

PGLYRP3

Peptidoglycan recognition protein 3

Also known as: PGLYRPIalpha, PGRP-Ialpha, PGRP3_HUMAN, PGRPIA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96LB9
Gene: PGLYRP3
Ensembl: ENSG00000159527
Chromosome: 1
Canonical length: 341 aa
Protein class: Metabolic proteins, Predicted secreted proteins
Secretome location: Secreted in other tissues
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]

Canonical amino-acid sequenceUniProt

341 residues, UniProt reviewed canonical sequence.

>Q96LB9|PGLYRP3
     1  MGTLPWLLAF FILGLQAWDT PTIVSRKEWG ARPLACRALL TLPVAYIITD QLPGMQCQQQ
    61  SVCSQMLRGL QSHSVYTIGW CDVAYNFLVG DDGRVYEGVG WNIQGLHTQG YNNISLGIAF
   121  FGNKIGSSPS PAALSAAEGL ISYAIQKGHL SPRYIQPLLL KEETCLDPQH PVMPRKVCPN
   181  IIKRSAWEAR ETHCPKMNLP AKYVIIIHTA GTSCTVSTDC QTVVRNIQSF HMDTRNFCDI
   241  GYHFLVGQDG GVYEGVGWHI QGSHTYGFND IALGIAFIGY FVEKPPNAAA LEAAQDLIQC
   301  AVVEGYLTPN YLLMGHSDVV NILSPGQALY NIISTWPHFK H

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PGLYRP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

skin: 49 nTPM
esophagus: 27 nTPM
tonsil: 5.3 nTPM
breast: 1.3 nTPM
choroid plexus: 1 nTPM
vagina: 0.8 nTPM

Single-cell type

esophageal apical cells: 227 nCPM
esophageal suprabasal cells: 73 nCPM
suprabasal keratinocytes: 60 nCPM
esophageal basal cells: 15 nCPM
basal keratinocytes: 13 nCPM
ocular epithelial cells: 12 nCPM

Immune cell

basophil: 8.4 nTPM
eosinophil: 3.7 nTPM
neutrophil: 0.5 nTPM
NK-cell: 0.1 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM

Brain region

pons: 14 nTPM
cerebral cortex: 12 nTPM
white matter: 11 nTPM
hippocampal formation: 9.6 nTPM
medulla oblongata: 7.4 nTPM
cerebellum: 6.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0
gnomAD missense Z: 0.54
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PGLYRP3 as an antibody target. Whether an autoantibody or antibody against PGLYRP3 could matter depends on whether native PGLYRP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PGLYRP3 is annotated as secreted, so native PGLYRP3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PGLYRP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...