Seroatlas · Human Serome Atlas

PGLS

6-phosphogluconolactonase

Also known as: 6PGL, 6PGL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95336
Gene: PGLS
Ensembl: ENSG00000130313
Chromosome: 19
Canonical length: 258 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables 6-phosphogluconolactonase activity. Involved in pentose-phosphate shunt. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

258 residues, UniProt reviewed canonical sequence.

>O95336|PGLS
     1  MAAPAPGLIS VFSSSQELGA ALAQLVAQRA ACCLAGARAR FALGLSGGSL VSMLARELPA
    61  AVAPAGPASL ARWTLGFCDE RLVPFDHAES TYGLYRTHLL SRLPIPESQV ITINPELPVE
   121  EAAEDYAKKL RQAFQGDSIP VFDLLILGVG PDGHTCSLFP DHPLLQEREK IVAPISDSPK
   181  PPPQRVTLTL PVLNAARTVI FVATGEGKAA VLKRILEDQE ENPLPAALVQ PHTGKLCWFL
   241  DEAAARLLTV PFEKHSTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PGLS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 107 nTPM

Expression across tissuesHPA

Tissue

esophagus: 107 nTPM
pancreas: 86 nTPM
adrenal gland: 85 nTPM
skin: 81 nTPM
liver: 75 nTPM
spleen: 73 nTPM

Single-cell type

esophageal apical cells: 556 nCPM
esophageal suprabasal cells: 445 nCPM
hofbauer cells: 390 nCPM
kupffer cells: 310 nCPM
esophageal basal cells: 283 nCPM
decidual stromal cells: 280 nCPM

Immune cell

eosinophil: 195 nTPM
intermediate monocyte: 186 nTPM
myeloid DC: 185 nTPM
non-classical monocyte: 181 nTPM
classical monocyte: 164 nTPM
neutrophil: 160 nTPM

Brain region

white matter: 48 nTPM
medulla oblongata: 45 nTPM
thalamus: 41 nTPM
pons: 40 nTPM
spinal cord: 40 nTPM
choroid plexus: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: 0.21
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

6-phosphogluconolactonase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PGLS as an antibody target. Whether an autoantibody or antibody against PGLS could matter depends on whether native PGLS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PGLS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PGLS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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