PGK2

Protein identityUniProt · HPA

UniProt accession

P07205

Gene

PGK2

Ensembl

ENSG00000170950

Chromosome

6

Canonical length

417 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Mid piece,Principal piece,End piece

OverviewNCBI Gene

This gene is intronless, arose via retrotransposition of the phosphoglycerate kinase 1 gene, and is expressed specifically in the testis. Initially assumed to be a pseudogene, the encoded protein is actually a functional phosphoglycerate kinase that catalyzes the reversible conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate, during the Embden-Meyerhof-Parnas pathway of glycolysis, in the later stages of spermatogenesis.[provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

417 residues, UniProt reviewed canonical sequence.

>P07205|PGK2
     1  MSLSKKLTLD KLDVRGKRVI MRVDFNVPMK KNQITNNQRI KASIPSIKYC LDNGAKAVVL
    61  MSHLGRPDGV PMPDKYSLAP VAVELKSLLG KDVLFLKDCV GAEVEKACAN PAPGSVILLE
   121  NLRFHVEEEG KGQDPSGKKI KAEPDKIEAF RASLSKLGDV YVNDAFGTAH RAHSSMVGVN
   181  LPHKASGFLM KKELDYFAKA LENPVRPFLA ILGGAKVADK IQLIKNMLDK VNEMIIGGGM
   241  AYTFLKVLNN MEIGASLFDE EGAKIVKDIM AKAQKNGVRI TFPVDFVTGD KFDENAQVGK
   301  ATVASGISPG WMGLDCGPES NKNHAQVVAQ ARLIVWNGPL GVFEWDAFAK GTKALMDEIV
   361  KATSKGCITV IGGGDTATCC AKWNTEDKVS HVSTGGGASL ELLEGKILPG VEALSNM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PGK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.23

Highest tissue expression

187 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.61

gnomAD pLI

0

gnomAD missense Z

-0.92

DepMap mean gene effect

0.11

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• canonical glycolysis
• flagellated sperm motility
• gluconeogenesis
• glycolytic process
• phosphorylation

Molecular functions

• ADP binding
• ATP binding
• metal ion binding
• phosphoglycerate kinase activity

Cellular components

• cytosol
• extracellular exosome
• nucleus
• sperm fibrous sheath

Protein domainsUniProt · Pfam · InterPro

• Phosphoglycerate kinase
• Phosphoglycerate kinase, N-terminal
• Phosphoglycerate kinase, conserved site
• Phosphoglycerate kinase superfamily
• Phosphoglycerate kinase

KeywordsUniProt

• Acetylation
• ATP-binding
• Cytoplasm
• Glycolysis
• Kinase
• Magnesium
• Metal-binding
• Nucleotide-binding
• Phosphoprotein
• Transferase

InteractionsUniProt · HPA

Protein binding partners of PGK2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PGK1