Seroatlas · Human Serome Atlas

PGGHG

Protein-glucosylgalactosylhydroxylysine glucosidase

Also known as: ATHL1, FLJ22635, PGGHG_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q32M88
Gene: PGGHG
Ensembl: ENSG00000142102
Chromosome: 11
Canonical length: 737 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables protein-glucosylgalactosylhydroxylysine glucosidase activity. Involved in carbohydrate metabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

737 residues, UniProt reviewed canonical sequence.

>Q32M88|PGGHG
     1  MEDAGEDPTT FAAHSLPSDP RLLATVTNAY LGTRVFHDTL HVSGVYNGAG GDTHRAMLPS
    61  PLNVRLEAPA GMGEQLTETF ALDTNTGSFL HTLEGPRFRA SQCIYAHRTL PHVLAFRVSI
   121  ARLAPGSGPI TLLLRSAFSP ESPDLDLHQG PDFQGARYLY GHTLTPEQPG GPQQEVHMLW
   181  TPAPPDLTLG EGEEARTWDF LTAVGGSQAE AQACLTEALQ LQARGALYTA HAQAWAQLWV
   241  ECGLDVVGPL QLRQALRGSL YYLLSALPQP KAPGYICHGL SPGGLSNGSR EECYWGHVFW
   301  DQDLWMFPSI LMFHPEAARA ILEYRIRTLD GALENAQNLG YQGAKFAWES ADSGLEVCPE
   361  DIYGVQEVHV NGAVVLAFEL YYHTTQDLQL FREAGGWDVV RAVAEFWCSR VEWSPREEKY
   421  HLRGVMSPDE YHSGVNNSVY TNVLVQNSLR FAAALAQDLG LPIPSQWLAV ADKIKVPFDV
   481  EQNFHPEFDG YEPGEVVKQA DVVLLGYPVP FSLSPDVRRK NLEIYEAVTS PQGPAMTWSM
   541  FAVGWMELKD AVRARGLLDR SFANMAEPFK VWTENADGSG AVNFLTGMGG FLQAVVFGCT
   601  GFRVTRAGVT FDPVCLSGIS RVSVSGIFYQ GNKLNFSFSE DSVTVEVTAR AGPWAPHLEA
   661  ELWPSQSRLS LLPGHKVSFP RSAGRIQMSP PKLPGSSSSE FPGRTFSDVR DPLQSPLWVT
   721  LGSSSPTESL TVDPASE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PGGHG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 623 nTPM

Expression across tissuesHPA

Tissue

pancreas: 623 nTPM
kidney: 146 nTPM
spleen: 100 nTPM
small intestine: 98 nTPM
liver: 75 nTPM
thyroid gland: 74 nTPM

Single-cell type

renal collecting duct principal cells: 122 nCPM
neutrophils: 105 nCPM
pancreatic acinar cells: 91 nCPM
papillary tip epithelial cells: 72 nCPM
innate lymphoid cells: 62 nCPM
loop of henle epithelial cells: 53 nCPM

Immune cell

gdT-cell: 6.1 nTPM
NK-cell: 5.6 nTPM
MAIT T-cell: 5.2 nTPM
naive CD8 T-cell: 4.6 nTPM
neutrophil: 3.7 nTPM
memory CD8 T-cell: 3.3 nTPM

Brain region

cerebral cortex: 51 nTPM
pons: 11 nTPM
thalamus: 8.7 nTPM
medulla oblongata: 8.1 nTPM
choroid plexus: 7.5 nTPM
midbrain: 6.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

carbohydrate metabolic process

Molecular functions

protein-glucosylgalactosylhydroxylysine glucosidase activity

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

Six-hairpin glycosidase superfamily
Six-hairpin glycosidase-like superfamily
Glycoside hydrolase, family 65, central catalytic
Glycosyl hydrolase family 65 central catalytic domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PGGHG as an antibody target. Whether an autoantibody or antibody against PGGHG could matter depends on whether native PGGHG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PGGHG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PGGHG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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