Seroatlas · Human Serome Atlas

PGBD5

PiggyBac transposable element-derived protein 5

Also known as: DKFZp761A0620, FLJ11413, PGBD5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N414
Gene
PGBD5
Ensembl
ENSG00000177614
Chromosome
1
Canonical length
524 aa
Protein class
Disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes, including human, that appear to have been derived from the piggyBac transposons. This gene belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

524 residues, UniProt reviewed canonical sequence.

>Q8N414|PGBD5
     1  MAEGGGGARR RAPALLEAAR ARYESLHISD DVFGESGPDS GGNPFYSTSA ASRSSSAASS
    61  DDEREPPGPP GAAPPPPRAP DAQEPEEDEA GAGWSAALRD RPPPRFEDTG GPTRKMPPSA
   121  SAVDFFQLFV PDNVLKNMVV QTNMYAKKFQ ERFGSDGAWV EVTLTEMKAF LGYMISTSIS
   181  HCESVLSIWS GGFYSNRSLA LVMSQARFEK ILKYFHVVAF RSSQTTHGLY KVQPFLDSLQ
   241  NSFDSAFRPS QTQVLHEPLI DEDPVFIATC TERELRKRKK RKFSLWVRQC SSTGFIIQIY
   301  VHLKEGGGPD GLDALKNKPQ LHSMVARSLC RNAAGKNYII FTGPSITSLT LFEEFEKQGI
   361  YCCGLLRARK SDCTGLPLSM LTNPATPPAR GQYQIKMKGN MSLICWYNKG HFRFLTNAYS
   421  PVQQGVIIKR KSGEIPCPLA VEAFAAHLSY ICRYDDKYSK YFISHKPNKT WQQVFWFAIS
   481  IAINNAYILY KMSDAYHVKR YSRAQFGERL VRELLGLEDA SPTH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PGBD5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 26 nTPM
  • cerebellum: 26 nTPM
  • hippocampal formation: 20 nTPM
  • pancreas: 19 nTPM
  • cervix: 17 nTPM
  • amygdala: 16 nTPM

Single-cell type

  • brain excitatory neurons: 172 nCPM
  • salivary acinar cells: 121 nCPM
  • thyrotrophs: 102 nCPM
  • brain inhibitory neurons: 90 nCPM
  • retinal amacrine cells: 86 nCPM
  • retinal bipolar cells: 85 nCPM

Immune cell

  • basophil: 0.1 nTPM
  • eosinophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hippocampal formation: 143 nTPM
  • cerebral cortex: 130 nTPM
  • amygdala: 92 nTPM
  • basal ganglia: 90 nTPM
  • white matter: 67 nTPM
  • cerebellum: 53 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PGBD5.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 17 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Neurodevelopmental disorder with seizures, hypotonia, and variable spasticity

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.71
gnomAD pLI
0
gnomAD missense Z
1.35

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

  • non-replicative DNA transposition

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PGBD5 as an antibody target. Whether an autoantibody or antibody against PGBD5 could matter depends on whether native PGBD5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PGBD5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PGBD5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PGBD5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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