Seroatlas · Human Serome Atlas

PGBD4

PiggyBac transposable element-derived protein 4

Also known as: FLJ32638, FLJ37497, PGBD4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96DM1
Gene
PGBD4
Ensembl
ENSG00000182405
Chromosome
15
Canonical length
585 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Centrosome

OverviewNCBI Gene

The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes, including human, that appear to have been derived from the piggyBac transposons. This gene belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

585 residues, UniProt reviewed canonical sequence.

>Q96DM1|PGBD4
     1  MSNPRKRSIP MRDSNTGLEQ LLAEDSFDES DFSEIDDSDN FSDSALEADK IRPLSHLESD
    61  GKSSTSSDSG RSMKWSARAM IPRQRYDFTG TPGRKVDVSD ITDPLQYFEL FFTEELVSKI
   121  TRETNAQAAL LASKPPGPKG FSRMDKWKDT DNDELKVFFA VMLLQGIVQK PELEMFWSTR
   181  PLLDTPYLRQ IMTGERFLLL FRCLHFVNNS SISAGQSKAQ ISLQKIKPVF DFLVNKFSTV
   241  YTPNRNIAVD ESLMLFKGPL AMKQYLPTKR VRFGLKLYVL CESQSGYVWN ALVHTGPGMN
   301  LKDSADGLKS SRIVLTLVND LLGQGYCVFL DNFNISPMLF RELHQNRTDA VGTARLNRKQ
   361  IPNDLKKRIA KGTTVARFCG ELMALKWCDG KEVTMLSTFH NDTVIEVNNR NGKKTKRPRV
   421  IVDYNENMGA VDSADQMLTS YPSERKRHKV WYKKFFHHLL HITVLNSYIL FKKDNPEHTM
   481  SHINFRLALI ERMLEKHHKP GQQHLRGRPC SDDVTPLRLS GRHFPKSIPA TSGKQNPTGR
   541  CKICCSQYDK DGKKIRKETR YFCAECDVPL CVVPCFEIYH TKKNY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PGBD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
4.9 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 4.9 nTPM
  • bone marrow: 2.6 nTPM
  • retina: 2.2 nTPM
  • cerebral cortex: 1.9 nTPM
  • lymph node: 1.9 nTPM
  • testis: 1.7 nTPM

Single-cell type

  • late spermatids: 15 nCPM
  • early spermatids: 12 nCPM
  • adrenal medulla cells: 11 nCPM
  • late primary spermatocytes: 11 nCPM
  • thymic myoid cells: 8.2 nCPM
  • bergmann glia: 8.1 nCPM

Immune cell

  • basophil: 3.8 nTPM
  • neutrophil: 1.1 nTPM
  • naive CD4 T-cell: 0.9 nTPM
  • naive B-cell: 0.8 nTPM
  • naive CD8 T-cell: 0.8 nTPM
  • eosinophil: 0.6 nTPM

Brain region

  • pons: 12 nTPM
  • cerebral cortex: 11 nTPM
  • medulla oblongata: 10 nTPM
  • hippocampal formation: 9.7 nTPM
  • white matter: 9.5 nTPM
  • cerebellum: 9.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.83
gnomAD pLI
0.34
gnomAD missense Z
1.49
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PGBD4 as an antibody target. Whether an autoantibody or antibody against PGBD4 could matter depends on whether native PGBD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PGBD4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PGBD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PGBD4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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