Seroatlas · Human Serome Atlas

PGAP6

Post-GPI attachment to proteins factor 6

Also known as: M83, PGAP6_HUMAN, TMEM6, TMEM8, TMEM8A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HCN3
Gene: PGAP6
Ensembl: ENSG00000129925
Chromosome: 16
Canonical length: 771 aa
Protein class: Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Cytokinetic bridge

OverviewNCBI Gene

Predicted to enable phospholipase A2 activity. Predicted to be involved in lipid metabolic process. Located in extracellular exosome and lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

771 residues, UniProt reviewed canonical sequence.

>Q9HCN3|PGAP6
     1  MGRAGTGTGG EAVAAVVAGP LLLLLLARPP PASAGYSGKS EVGLVSEHFS QAPQRLSFYS
    61  WYGSARLFRF RVPPDAVLLR WLLQVSRESG AACTDAEITV HFRSGAPPVI NPLGTSFPDD
   121  TAVQPSFQVG VPLSTTPRSN ASVNVSHPAP GDWFVAAHLP PSSQKIELKG LAPTCAYVFQ
   181  PELLVTRVVE ISIMEPDVPL PQTLLSHPSY LKVFVPDYTR ELLLELRDCV SNGSLGCPVR
   241  LTVGPVTLPS NFQKVLTCTG APWPCRLLLP SPPWDRWLQV TAESLVGPLG TVAFSAVAAL
   301  TACRPRSVTI QPLLQSSQNQ SFNASSGLLS PSPDHQDLGR SGRVDRSPFC LTNYPVTRED
   361  MDVVSVHFQP LDRVSVRVCS DTPSVMRLRL NTGMDSGGSL TISLRANKTE MRNETVVVAC
   421  VNAASPFLGF NTSLNCTTAF FQGYPLSLSA WSRRANLIIP YPETDNWYLS LQLMCPENAE
   481  DCEQAVVHVE TTLYLVPCLN DCGPYGQCLL LRRHSYLYAS CSCKAGWRGW SCTDNSTAQT
   541  VAQQRAATLL LTLSNLMFLA PIAVSVRRFF LVEASVYAYT MFFSTFYHAC DQPGEAVLCI
   601  LSYDTLQYCD FLGSGAAIWV TILCMARLKT VLKYVLFLLG TLVIAMSLQL DRRGMWNMLG
   661  PCLFAFVIMA SMWAYRCGHR RQCYPTSWQR WAFYLLPGVS MASVGIAIYT SMMTSDNYYY
   721  THSIWHILLA GSAALLLPPP DQPAEPWACS QKFPCHYQIC KNDREELYAV T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PGAP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 100 nTPM

Expression across tissuesHPA

Tissue

pancreas: 100 nTPM
testis: 62 nTPM
liver: 56 nTPM
kidney: 53 nTPM
stomach: 52 nTPM
salivary gland: 39 nTPM

Single-cell type

late spermatids: 175 nCPM
early spermatids: 114 nCPM
esophageal apical cells: 80 nCPM
epididymal principal cells: 80 nCPM
syncytiotrophoblasts: 77 nCPM
neutrophils: 66 nCPM

Immune cell

neutrophil: 36 nTPM
gdT-cell: 11 nTPM
naive CD4 T-cell: 11 nTPM
eosinophil: 10 nTPM
intermediate monocyte: 8.6 nTPM
MAIT T-cell: 8.3 nTPM

Brain region

thalamus: 33 nTPM
basal ganglia: 29 nTPM
medulla oblongata: 29 nTPM
choroid plexus: 28 nTPM
white matter: 28 nTPM
pons: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

lipid metabolic process

Molecular functions

phospholipase A2 activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PGAP6 as an antibody target. Whether an autoantibody or antibody against PGAP6 could matter depends on whether native PGAP6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PGAP6 is annotated at the cell surface, where native PGAP6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PGAP6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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