Seroatlas · Human Serome Atlas

PGAM4

Probable phosphoglycerate mutase 4

Also known as: dJ1000K24.1, PGAM-B, PGAM1, PGAM3, PGAM4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N0Y7
Gene: PGAM4
Ensembl: ENSG00000226784
Chromosome: X
Canonical length: 254 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mid piece

OverviewNCBI Gene

This intronless gene appears to have arisen from a retrotransposition event, yet it is thought to be an expressed, protein-coding gene. The encoded protein is a member of the phosphoglycerate mutase family, a set of enzymes that catalyze the transfer of a phosphate group from 3-phosphoglycerate to 2-phosphoglycerate. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

254 residues, UniProt reviewed canonical sequence.

>Q8N0Y7|PGAM4
     1  MAAYKLVLIR HGESTWNLEN RFSCWYDADL SPAGHEEAKR GGQALRDAGY EFDICLTSVQ
    61  KRVIRTLWTV LDAIDQMWLP VVRTWRLNER HYGGLTGLNK AETAAKHGEA QVKIWRRSYD
   121  VPPPPMEPDH PFYSNISKDR RYADLTEDQL PSYESPKDTI ARALPFWNEE IVPQIKEGKR
   181  VLIAAHGNSL QGIAKHVEGL SEEAIMELNL PTGIPIVYEL DKNLKPIKPM QFLGDEETVC
   241  KAIEAVAAQG KAKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PGAM4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 1.2 nTPM

Expression across tissuesHPA

Tissue

esophagus: 1.2 nTPM
adrenal gland: 0.9 nTPM
cerebral cortex: 0.7 nTPM
vagina: 0.7 nTPM
endometrium: 0.6 nTPM
heart muscle: 0.6 nTPM

Single-cell type

cardiomyocytes: 0.8 nCPM
esophageal apical cells: 0.8 nCPM
esophageal suprabasal cells: 0.6 nCPM
esophageal basal cells: 0.4 nCPM
migrating cytotrophoblasts: 0.4 nCPM
hepatocytes: 0.3 nCPM

Immune cell

total PBMC: 1.7 nTPM
eosinophil: 1.5 nTPM
non-classical monocyte: 1.1 nTPM
classical monocyte: 1 nTPM
intermediate monocyte: 1 nTPM
T-reg: 0.9 nTPM

Brain region

cerebral cortex: 1.4 nTPM
hippocampal formation: 1.1 nTPM
pons: 1 nTPM
basal ganglia: 0.9 nTPM
white matter: 0.9 nTPM
hypothalamus: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.2
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PGAM4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PGAM2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PGAM4 as an antibody target. Whether an autoantibody or antibody against PGAM4 could matter depends on whether native PGAM4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PGAM4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PGAM4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...