Seroatlas · Human Serome Atlas

PEX16

Peroxisomal membrane protein PEX16

Also known as: PEX16_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y5Y5
Gene
PEX16
Ensembl
ENSG00000121680
Chromosome
11
Canonical length
336 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is an integral peroxisomal membrane protein. An inactivating nonsense mutation localized to this gene was observed in a patient with Zellweger syndrome of the complementation group CGD/CG9. Expression of this gene product morphologically and biochemically restores the formation of new peroxisomes, suggesting a role in peroxisome organization and biogenesis. Alternative splicing has been observed for this gene and two variants have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

336 residues, UniProt reviewed canonical sequence.

>Q9Y5Y5|PEX16
     1  MEKLRLLGLR YQEYVTRHPA ATAQLETAVR GFSYLLAGRF ADSHELSELV YSASNLLVLL
    61  NDGILRKELR KKLPVSLSQQ KLLTWLSVLE CVEVFMEMGA AKVWGEVGRW LVIALVQLAK
   121  AVLRMLLLLW FKAGLQTSPP IVPLDRETQA QPPDGDHSPG NHEQSYVGKR SNRVVRTLQN
   181  TPSLHSRHWG APQQREGRQQ QHHEELSATP TPLGLQETIA EFLYIARPLL HLLSLGLWGQ
   241  RSWKPWLLAG VVDVTSLSLL SDRKGLTRRE RRELRRRTIL LLYYLLRSPF YDRFSEARIL
   301  FLLQLLADHV PGVGLVTRPL MDYLPTWQKI YFYSWG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PEX16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • liver: 45 nTPM
  • amygdala: 38 nTPM
  • hippocampal formation: 37 nTPM
  • pancreas: 35 nTPM
  • basal ganglia: 35 nTPM
  • cerebral cortex: 34 nTPM

Single-cell type

  • enterocytes: 94 nCPM
  • syncytiotrophoblasts: 76 nCPM
  • hepatocytes: 71 nCPM
  • breast lactating cells: 64 nCPM
  • late spermatids: 54 nCPM
  • esophageal suprabasal cells: 53 nCPM

Immune cell

  • T-reg: 61 nTPM
  • memory B-cell: 57 nTPM
  • intermediate monocyte: 51 nTPM
  • naive B-cell: 51 nTPM
  • memory CD8 T-cell: 50 nTPM
  • memory CD4 T-cell: 49 nTPM

Brain region

  • medulla oblongata: 34 nTPM
  • white matter: 32 nTPM
  • midbrain: 29 nTPM
  • basal ganglia: 29 nTPM
  • thalamus: 29 nTPM
  • cerebellum: 28 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PEX16.

Disease | AllUniProt

Conditions PEX16 is implicated in, by any mechanism.

  • Peroxisome biogenesis disorder complementation group 9 (PBD-CG9) MIM:614876
  • Peroxisome biogenesis disorder 8A (PBD8A) MIM:614876
  • Peroxisome biogenesis disorder 8B (PBD8B) MIM:614877

Disease | GeneticClinVar

42 pathogenic / likely-pathogenic of 666 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.83
gnomAD pLI
0
gnomAD missense Z
0.45
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Peroxisome membrane protein, Pex16
  • Peroxisomal membrane protein (Pex16)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PEX16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PEX16 as an antibody target. Whether an autoantibody or antibody against PEX16 could matter depends on whether native PEX16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PEX16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PEX16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PEX16. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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