Seroatlas · Human Serome Atlas

PEX11G

Peroxisomal membrane protein 11C

Also known as: PEX11gamma, PX11C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96HA9
Gene: PEX11G
Ensembl: ENSG00000104883
Chromosome: 19
Canonical length: 241 aa
Protein class: Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the PEX11 family. This family is reported to regulate the number and size of peroxisomes in evolutionarily distant organisms. The protein encoded by this gene may induce clustering of peroxisomes. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

241 residues, UniProt reviewed canonical sequence.

>Q96HA9|PEX11G
     1  MASLSGLASA LESYRGRDRL IRVLGYCCQL VGGVLVEQCP ARSEVGTRLL VVSTQLSHCR
    61  TILRLFDDLA MFVYTKQYGL GAQEEDAFVR CVSVLGNLAD QLYYPCEHVA WAADARVLHV
   121  DSSRWWTLST TLWALSLLLG VARSLWMLLK LRQRLRSPTA PFTSPLPRGK RRAMEAQMQS
   181  EALSLLSNLA DLANAVHWLP RGVLWAGRFP PWLVGLMGTI SSILSMYQAA RAGGQAEATT
   241  P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PEX11G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

testis: 28 nTPM
liver: 25 nTPM
adrenal gland: 11 nTPM
kidney: 9.8 nTPM
spinal cord: 6.3 nTPM
duodenum: 6.2 nTPM

Single-cell type

early spermatids: 138 nCPM
late spermatids: 121 nCPM
late primary spermatocytes: 67 nCPM
endometrial luminal cells: 49 nCPM
enterocytes: 44 nCPM
hepatocytes: 43 nCPM

Immune cell

basophil: 25 nTPM
eosinophil: 16 nTPM
neutrophil: 13 nTPM
NK-cell: 7.9 nTPM
naive B-cell: 4.1 nTPM
classical monocyte: 3.9 nTPM

Brain region

white matter: 9.4 nTPM
basal ganglia: 9.3 nTPM
midbrain: 7.5 nTPM
cerebral cortex: 7.4 nTPM
medulla oblongata: 7.2 nTPM
thalamus: 6.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.66
gnomAD pLI: 0
gnomAD missense Z: -0.35
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Peroxisomal biogenesis factor 11
Peroxisomal biogenesis factor 11 (PEX11)
Peroxisomal membrane protein 11C, metazoa

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PEX11G in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

FIS1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PEX11G as an antibody target. Whether an autoantibody or antibody against PEX11G could matter depends on whether native PEX11G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PEX11G is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PEX11G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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