Seroatlas · Human Serome Atlas

PEX11B

Peroxisomal membrane protein 11B

Also known as: PEX11beta, PX11B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O96011
Gene
PEX11B
Ensembl
ENSG00000131779
Chromosome
1
Canonical length
259 aa
Protein class
Disease related genes, Human disease related genes, Predicted membrane proteins
Subcellular location
Nucleoplasm,Vesicles
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene facilitates peroxisomal proliferation and interacts with PEX19. The encoded protein is found in the peroxisomal membrane. Several transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

259 residues, UniProt reviewed canonical sequence.

>O96011|PEX11B
     1  MDAWVRFSAQ SQARERLCRA AQYACSLLGH ALQRHGASPE LQKQIRQLES HLSLGRKLLR
    61  LGNSADALES AKRAVHLSDV VLRFCITVSH LNRALYFACD NVLWAGKSGL APRVDQEKWA
   121  QRSFRYYLFS LIMNLSRDAY EIRLLMEQES SACSRRLKGS GGGVPGGSET GGLGGPGTPG
   181  GGLPQLALKL RLQVLLLARV LRGHPPLLLD VVRNACDLFI PLDKLGLWRC GPGIVGLCGL
   241  VSSILSILTL IYPWLRLKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PEX11B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
49 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 49 nTPM
  • basal ganglia: 40 nTPM
  • hypothalamus: 40 nTPM
  • skeletal muscle: 40 nTPM
  • hippocampal formation: 36 nTPM
  • cerebellum: 36 nTPM

Single-cell type

  • oocytes: 65 nCPM
  • early primary spermatocytes: 60 nCPM
  • parietal cells: 51 nCPM
  • esophageal suprabasal cells: 50 nCPM
  • megakaryocytes: 50 nCPM
  • cytotrophoblasts: 49 nCPM

Immune cell

  • plasmacytoid DC: 95 nTPM
  • memory B-cell: 94 nTPM
  • basophil: 90 nTPM
  • naive B-cell: 85 nTPM
  • total PBMC: 83 nTPM
  • T-reg: 80 nTPM

Brain region

  • hypothalamus: 41 nTPM
  • cerebral cortex: 37 nTPM
  • basal ganglia: 35 nTPM
  • pons: 35 nTPM
  • white matter: 32 nTPM
  • hippocampal formation: 32 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PEX11B.

Disease | AllUniProt

Conditions PEX11B is implicated in, by any mechanism.

  • Peroxisome biogenesis disorder 14B (PBD14B) MIM:614920

Disease | GeneticClinVar

14 pathogenic / likely-pathogenic of 261 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0
gnomAD missense Z
-0.31
DepMap mean gene effect
-0.29
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PEX11B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PEX11B as an antibody target. Whether an autoantibody or antibody against PEX11B could matter depends on whether native PEX11B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PEX11B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PEX11B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PEX11B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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