Seroatlas · Human Serome Atlas

PEX10

Peroxisome biogenesis factor 10

Also known as: PEX10_HUMAN, RNF69

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60683
Gene
PEX10
Ensembl
ENSG00000157911
Chromosome
1
Canonical length
326 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a protein involved in import of peroxisomal matrix proteins. This protein localizes to the peroxisomal membrane. Mutations in this gene result in phenotypes within the Zellweger spectrum of peroxisomal biogenesis disorders, ranging from neonatal adrenoleukodystrophy to Zellweger syndrome. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

326 residues, UniProt reviewed canonical sequence.

>O60683|PEX10
     1  MAPAAASPPE VIRAAQKDEY YRGGLRSAAG GALHSLAGAR KWLEWRKEVE LLSDVAYFGL
    61  TTLAGYQTLG EEYVSIIQVD PSRIHVPSSL RRGVLVTLHA VLPYLLDKAL LPLEQELQAD
   121  PDSGRPLQGS LGPGGRGCSG ARRWMRHHTA TLTEQQRRAL LRAVFVLRQG LACLQRLHVA
   181  WFYIHGVFYH LAKRLTGITY LRVRSLPGED LRARVSYRLL GVISLLHLVL SMGLQLYGFR
   241  QRQRARKEWR LHRGLSHRRA SLEERAVSRN PLCTLCLEER RHPTATPCGH LFCWECITAW
   301  CSSKAECPLC REKFPPQKLI YLRHYR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PEX10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
5
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 34 nTPM
  • amygdala: 32 nTPM
  • midbrain: 31 nTPM
  • cerebral cortex: 31 nTPM
  • basal ganglia: 30 nTPM
  • hippocampal formation: 28 nTPM

Single-cell type

  • late spermatids: 367 nCPM
  • early primary spermatocytes: 69 nCPM
  • early spermatids: 57 nCPM
  • differentiating spermatogonia: 52 nCPM
  • esophageal suprabasal cells: 49 nCPM
  • epididymal principal cells: 47 nCPM

Immune cell

  • myeloid DC: 9.4 nTPM
  • intermediate monocyte: 8.7 nTPM
  • plasmacytoid DC: 7.8 nTPM
  • non-classical monocyte: 7.6 nTPM
  • memory B-cell: 6 nTPM
  • classical monocyte: 5.8 nTPM

Brain region

  • medulla oblongata: 35 nTPM
  • white matter: 34 nTPM
  • basal ganglia: 32 nTPM
  • spinal cord: 31 nTPM
  • thalamus: 31 nTPM
  • cerebellum: 31 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PEX10.

Disease | AllUniProt

Conditions PEX10 is implicated in, by any mechanism.

  • Peroxisome biogenesis disorder complementation group 7 (PBD-CG7) MIM:614870
  • Peroxisome biogenesis disorder 6A (PBD6A) MIM:614870
  • Peroxisome biogenesis disorder 6B (PBD6B) MIM:614871

Disease | GeneticClinVar

142 pathogenic / likely-pathogenic of 864 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0
gnomAD missense Z
-0.29
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PEX10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PEX10 as an antibody target. Whether an autoantibody or antibody against PEX10 could matter depends on whether native PEX10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PEX10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PEX10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PEX10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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