Seroatlas · Human Serome Atlas

PERM1

PGC-1 and ERR-induced regulator in muscle protein 1

Also known as: C1orf170, MGC13275, PERM1_HUMAN, RP11-54O7.8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5SV97
Gene
PERM1
Ensembl
ENSG00000187642
Chromosome
1
Canonical length
790 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Involved in response to muscle activity. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

790 residues, UniProt reviewed canonical sequence.

>Q5SV97|PERM1
     1  MENFQYSVQL SDQDWAEFSA TADECGLLQA GLASGDELLS SDIDQGDSSG SSPPRAPPLP
    61  TGQLAAGGRS RRGCEEEDVA TQQPVSRSQG EPVLALGTGQ QTPSTSARAE APPSLGPGAS
   121  PPSQFSSCPG PASSGDQMQR LLQGPAPRPP GEPPGSPKSP GHSTGSQRPP DSPGAPPRSP
   181  SRKKRRAVGA KGGGHTGASA SAQTGSPLLP AASPETAKLM AKAGQEELGP GPAGAPEPGP
   241  RSPVQEDRPG PGLGLSTPVP VTEQGTDQIR TPRRAKLHTV STTVWEALPD VSRAKSDMAV
   301  STPASEPQPD RDMAVSTPAS EPQSDRDMAV STPASEPQPD TDMAVSTPAS EPQPDRDMAV
   361  SIPASKPQSD TAVSTPASEP QSSVALSTPI SKPQLDTDVA VSTPASKHGL DVALPTAGPV
   421  AKLEVASSPP VSEAVPRMTE SSGLVSTPVP RADAAGLAWP PTRRAGPDVV EMEAVVSEPS
   481  AGAPGCCSGA PALGLTQVPR KKKVRFSVAG PSPNKPGSGQ ASARPSAPQT ATGAHGGPGA
   541  WEAVAVGPRP HQPRILKHLP RPPPSAVTRV GPGSSFAVTL PEAYEFFFCD TIEENEEAEA
   601  AAAGQDPAGV QWPDMCEFFF PDVGAQRSRR RGSPEPLPRA DPVPAPIPGD PVPISIPEVY
   661  EHFFFGEDRL EGVLGPAVPL PLQALEPPRS ASEGAGPGTP LKPAVVERLH LALRRAGELR
   721  GPVPSFAFSQ NDMCLVFVAF ATWAVRTSDP HTPDAWKTAL LANVGTISAI RYFRRQVGQG
   781  RRSHSPSPSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PERM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.7
Highest tissue expression
168 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 168 nTPM
  • tongue: 127 nTPM
  • heart muscle: 64 nTPM
  • salivary gland: 2.1 nTPM
  • esophagus: 1.9 nTPM
  • skin: 1.1 nTPM

Single-cell type

  • myonuclei: 77 nCPM
  • cardiomyocytes: 74 nCPM
  • late primary spermatocytes: 11 nCPM
  • late spermatids: 9.8 nCPM
  • epididymal principal cells: 7.9 nCPM
  • early spermatids: 5.9 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • midbrain: 0.6 nTPM
  • basal ganglia: 0.5 nTPM
  • cerebral cortex: 0.5 nTPM
  • amygdala: 0.2 nTPM
  • hippocampal formation: 0.2 nTPM
  • medulla oblongata: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.69
gnomAD pLI
0

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • PGC-1 and ERR-induced regulator in muscle protein 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PERM1 as an antibody target. Whether an autoantibody or antibody against PERM1 could matter depends on whether native PERM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PERM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PERM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PERM1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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