Seroatlas · Human Serome Atlas

PERCC1

Protein PERCC1

Also known as: PERC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1W2PR82
Gene
PERCC1
Ensembl
ENSG00000284395
Chromosome
16
Canonical length
267 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in digestive tract morphogenesis and enteroendocrine cell differentiation. Implicated in congenital diarrhea. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

267 residues, UniProt reviewed canonical sequence.

>A0A1W2PR82|PERCC1
     1  MAAGVIRPLC DFQLPLLRHH PFLPSDPEPP ETSEEEEEEE EEEEEEEGEG EGLGGCGRIL
    61  PSSGRAEATE EAAPEGPGSP ETPLQLLRFS ELISDDIRRY FGRKDKGQDP DACDVYADSR
   121  PPRSTARELY YADLVRLARG GSLEDEDTPE PRVPQGQVCR PGLSGDRAQP LGPLAELFDY
   181  GLQQYWGSRA AAGWSLTLER KYGHITPMAQ RKLPPSFWKE PTPSPLGLLH PGTPDFSDLL
   241  ASWSTEACPE LPGRGTPALE GARPAEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PERCC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
1.7 nTPM

Expression across tissuesHPA

Tissue

  • prostate: 1.7 nTPM
  • stomach: 1.5 nTPM
  • cerebellum: 0.7 nTPM
  • duodenum: 0.6 nTPM
  • pituitary gland: 0.4 nTPM
  • thyroid gland: 0.4 nTPM

Single-cell type

  • prostatic glandular cells: 0.4 nCPM
  • müller glia: 0.3 nCPM
  • cardiomyocytes: 0.2 nCPM
  • pancreatic islet cells: 0.1 nCPM
  • respiratory ciliated cells: 0.1 nCPM
  • rod photoreceptor cells: 0.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 2.2 nTPM
  • basal ganglia: 2 nTPM
  • cerebral cortex: 2 nTPM
  • white matter: 1.9 nTPM
  • amygdala: 1.6 nTPM
  • medulla oblongata: 1.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PERCC1.

Disease | AllUniProt

Conditions PERCC1 is implicated in, by any mechanism.

  • Diarrhea 11, malabsorptive, congenital (DIAR11) MIM:618662

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 9 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Diarrhea 11, malabsorptive, congenital

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PERCC1 as an antibody target. Whether an autoantibody or antibody against PERCC1 could matter depends on whether native PERCC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PERCC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PERCC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PERCC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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