Seroatlas · Human Serome Atlas

PEDS1

Plasmanylethanolamine desaturase 1

Also known as: CarF, Kua, PEDS1_HUMAN, TMEM189

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A5PLL7
Gene: PEDS1
Ensembl: ENSG00000240849
Chromosome: 20
Canonical length: 270 aa
Protein class: Enzymes, Predicted membrane proteins
Subcellular location: Endoplasmic reticulum

OverviewNCBI Gene

Co-transcription of this gene and the neighboring downstream gene (ubiquitin-conjugating enzyme E2 variant 1) generates a rare read-through transcript, which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. The protein encoded by this individual gene lacks a UEV1 domain but includes three transmembrane regions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]

Canonical amino-acid sequenceUniProt

270 residues, UniProt reviewed canonical sequence.

>A5PLL7|PEDS1
     1  MAGAENWPGQ QLELDEDEAS CCRWGAQHAG ARELAALYSP GKRLQEWCSV ILCFSLIAHN
    61  LVHLLLLARW EDTPLVILGV VAGALIADFL SGLVHWGADT WGSVELPIVG KAFIRPFREH
   121  HIDPTAITRH DFIETNGDNC LVTLLPLLNM AYKFRTHSPE ALEQLYPWEC FVFCLIIFGT
   181  FTNQIHKWSH TYFGLPRWVT LLQDWHVILP RKHHRIHHVS PHETYFCITT GWLNYPLEKI
   241  GFWRRLEDLI QGLTGEKPRA DDMKWAQKIK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PEDS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 30 nTPM
esophagus: 27 nTPM
skin: 23 nTPM
midbrain: 21 nTPM
heart muscle: 21 nTPM
smooth muscle: 20 nTPM

Single-cell type

late spermatids: 154 nCPM
oligodendrocytes: 38 nCPM
microglia: 17 nCPM
early spermatids: 15 nCPM
brain inhibitory neurons: 14 nCPM
oligodendrocyte progenitor cells: 13 nCPM

Immune cell

non-classical monocyte: 14 nTPM
intermediate monocyte: 10 nTPM
eosinophil: 6.2 nTPM
myeloid DC: 5.6 nTPM
T-reg: 5.6 nTPM
classical monocyte: 5.3 nTPM

Brain region

white matter: 37 nTPM
medulla oblongata: 32 nTPM
cerebellum: 31 nTPM
midbrain: 29 nTPM
pons: 28 nTPM
basal ganglia: 27 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PEDS1.

Disease | ImmuneIEDB

Conditions an epitope on PEDS1 was assayed in.

castration-resistant prostate carcinoma B and T cell
prostate cancer B and T cell
cervical squamous cell carcinoma B and T cell
gastric adenocarcinoma B and T cell
prostate adenocarcinoma B and T cell
cancer B cell
esophageal cancer B and T cell
carcinoma B and T cell
triple-receptor negative breast cancer B and T cell
colorectal cancer B and T cell
cellular schwannoma B and T cell
lung cancer B and T cell
prostatic urethral cancer B and T cell
pancreatic carcinoma B cell
lung small cell carcinoma B cell
adult hepatocellular carcinoma B cell
Her2-receptor negative breast cancer B cell
hematologic cancer B cell
hepatocellular carcinoma B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.7
gnomAD pLI: 0
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

plasmanylethanolamine desaturase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Lipid desaturase domain
Plasmanylethanolamine desaturase
Lipid desaturase domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PEDS1 as an antibody target. Whether an autoantibody or antibody against PEDS1 could matter depends on whether native PEDS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PEDS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PEDS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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