Seroatlas · Human Serome Atlas

PDZRN4

PDZ domain-containing RING finger protein 4

Also known as: DKFZp434B0417, FLJ33777, IMAGE5767589, LNX4, PZRN4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZMN7
Gene: PDZRN4
Ensembl: ENSG00000165966
Chromosome: 12
Canonical length: 1036 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1036 residues, UniProt reviewed canonical sequence.

>Q6ZMN7|PDZRN4
     1  MGFALERFAE AVDPALECKL CGQVLEEPLC TPCGHVFCAS CLLPWAVRRR RCPLQCQPLA
    61  PGELYRVLPL RSLIQKLRVQ CDYRARGCGH SVRLHELEAH VEHCDFGPAR RLRSRGGCAS
   121  GLGGGEVPAR GGCGPTPRAG RGGGARGGPP GGRWGRGRGP GPRVLAWRRR EKALLAQLWA
   181  LQGEVQLTAR RYQEKFTQYM AHVRNFVGDL GGGHRRDGEH KPFTIVLERE NDTLGFNIIG
   241  GRPNQNNQEG TSTEGIYVSK ILENGPADRA DGLEIHDKIM EVNGKDLSKA THEEAVEAFR
   301  NAKEPIVVQV LRRTPLSRPA YGMASEVQLM NASTQTDITF EHIMALAKLR PPTPPVPDIC
   361  PFLLSDSCHS LHPMEHEFYE DNEYISSLPA DADRTEDFEY EEVELCRVSS QEKLGLTVCY
   421  RTDDEEDTGI YVSEVDPNSI AAKDGRIREG DRILQINGED VQNREEAVAL LSNDECKRIV
   481  LLVARPEIQL DEGWLEDERN EFLEELNLEM LEEEHNEAMQ PTANEVEQPK KQEEEEGTTD
   541  TATSSSNNHE KDSGVGRTDE SLRNDESSEQ ENAAEDPNST SLKSKRDLGQ SQDTLGSVEL
   601  QYNESLVSGE YIDSDCIGNP DEDCERFRQL LELKCKIRNH GEYDLYYSSS TIECNQGEQE
   661  GVEHELQLLN EELRNIELEC QNIMQAHRLQ KVTDQYGDIW TLHDGGFRNY NTSIDMQRGK
   721  LDDIMEHPEK SDKDSSSAYN TAESCRSTPL TVDRSPDSSL PRVINLTNKK NLRSTMAATQ
   781  SSSGQSSKES TSTKAKTTEQ GCSAESKEKV LEGSKLPDQE KAVSEHIPYL SPYHSSSYRY
   841  ANIPAHARHY QSYMQLIQQK SAVEYAQSQL SLVSMCKESQ KCSEPKMEWK VKIRSDGTRY
   901  ITKRPVRDRI LKERALKIKE ERSGMTTDDD TMSEMKMGRY WSKEERKQHL VRAKEQRRRR
   961  EFMMRSRLEC LKESPQSGSE GKKEINIIEL SHKKMMKKRN KKILDNWMTI QELMTHGAKS
  1021  PDGTRVHNAF LSVTTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDZRN4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

seminal vesicle: 17 nTPM
colon: 15 nTPM
blood vessel: 14 nTPM
urinary bladder: 6.7 nTPM
prostate: 6.2 nTPM
stomach: 4.4 nTPM

Single-cell type

peritubular myoid cells: 1,469 nCPM
oligodendrocyte progenitor cells: 962 nCPM
leydig cells: 914 nCPM
bergmann glia: 615 nCPM
corticotrophs: 587 nCPM
smooth muscle cells: 496 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 11 nTPM
cerebral cortex: 8.5 nTPM
pons: 8 nTPM
white matter: 7.1 nTPM
basal ganglia: 6.4 nTPM
medulla oblongata: 6.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.61
gnomAD pLI: 0
gnomAD missense Z: -0.06
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

zinc ion binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDZRN4 as an antibody target. Whether an autoantibody or antibody against PDZRN4 could matter depends on whether native PDZRN4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDZRN4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PDZRN4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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