Seroatlas · Human Serome Atlas

PDZK1P1

Putative PDZ domain-containing protein PDZK1P1

Also known as: PDZ1P_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MUH7
Gene: PDZK1P1
Canonical length: 402 aa

OverviewNCBI Gene

No narrative summary is available for PDZK1P1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

402 residues, UniProt reviewed canonical sequence.

>A8MUH7|PDZK1P1
     1  MNGGVQTWTQ PRLCYLVKEG GSHGFSLKTV QGKKGVYMTD ITPQGVAMRA GVLADDHLIE
    61  VNGENVEDAS HEEVVEKVKK SGSRVMFLLV DKETDKRHVE QKIQFKRETA SLKLLPHQPR
   121  IVEMKKGSNG YGFYLRAGSE QKGWGRVGQI IKDIDSGSPA EEAGLKNNDL VVAVNGESVE
   181  TLDHDSVVEM IRKGGDQTSL LVVDKETDNM YRLAHFSPFL YYQSQELPNG SVKEAPAPTP
   241  TSLEVSSPPD TTEEEDHKPK LCRLAKGENG YGFHLNAIRG LPGSFIKEVQ KGGPADLAGL
   301  EDEDVIIEVN GVNVLDEPYE KVVDRIQSSG KNVTLLVCGK KAYDYFQAKK IPIVSSLADP
   361  LDTPPDSKEG IVVESKHDSH MAKERAHSTA SHSSSNSEDT EM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDZK1P1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein localization to plasma membrane

Molecular functions

Cellular components

apical plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Repeat

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDZK1P1 as an antibody target. Whether an autoantibody or antibody against PDZK1P1 could matter depends on whether native PDZK1P1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDZK1P1 is annotated at the cell surface, where native PDZK1P1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PDZK1P1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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