PDZK1IP1
PDZK1-interacting protein 1
Also known as: DD96, MAP17, PDZ1I_HUMAN, SPAP
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q13113
- Gene
- PDZK1IP1
- Ensembl
- ENSG00000162366
- Chromosome
- 1
- Canonical length
- 114 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Nuclear speckles,Cytosol
OverviewNCBI Gene
Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
114 residues, UniProt reviewed canonical sequence.
>Q13113|PDZK1IP1
1 MSALSLLILG LLTAVPPASC QQGLGNLQPW MQGLIAVAVF LVLVAIAFAV NHFWCQEEPE
61 PAHMILTVGN KADGVLVGTD GRYSSMAASF RSSEHENAYE NVPEEEGKVR STPMLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PDZK1IP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.59
- Highest tissue expression
- 1,034 nTPM
Expression across tissuesHPA
Tissue
- kidney: 1,034 nTPM
- salivary gland: 195 nTPM
- esophagus: 194 nTPM
- gallbladder: 186 nTPM
- skin: 147 nTPM
- pancreas: 94 nTPM
Single-cell type
- esophageal apical cells: 2,333 nCPM
- esophageal suprabasal cells: 628 nCPM
- breast lactating cells: 532 nCPM
- endometrial secretory cells: 501 nCPM
- epididymal efferent duct absorptive cells: 420 nCPM
- gastric progenitor cells: 294 nCPM
Immune cell
- total PBMC: 144 nTPM
- neutrophil: 6.6 nTPM
- classical monocyte: 3.4 nTPM
- myeloid DC: 1.7 nTPM
- plasmacytoid DC: 1.5 nTPM
- intermediate monocyte: 1.1 nTPM
Brain region
- thalamus: 1.4 nTPM
- basal ganglia: 1.2 nTPM
- pons: 1 nTPM
- choroid plexus: 0.9 nTPM
- hypothalamus: 0.9 nTPM
- amygdala: 0.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.6
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.42
- DepMap mean gene effect
- -0.3
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of PDZK1IP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PDZK1IP1 as an antibody target. Whether an autoantibody or antibody against PDZK1IP1 could matter depends on whether native PDZK1IP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PDZK1IP1 is annotated at the cell surface, where native PDZK1IP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label PDZK1IP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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