Seroatlas · Human Serome Atlas

PDZD9

PDZ domain-containing protein 9

Also known as: C16orf65, MGC50721, PDZD9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IXQ8
Gene
PDZD9
Ensembl
ENSG00000155714
Chromosome
16
Canonical length
264 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for PDZD9 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

264 residues, UniProt reviewed canonical sequence.

>Q8IXQ8|PDZD9
     1  MQKASHKNKK ERGVSNKVKT SVHNLSKTQQ TKLTVGSLGL GLIIIQHGPY LQITHLIRKG
    61  AAANDGKLQP GDVLISVGHA NVLGYTLREF LQLLQHITIG TVLQIKVYRD FINIPEEWQE
   121  IYDLIPEAKF PVTSTPKKIE LAKDESFTSS DDNENVDLDK RLQYYRYPWS TVHHPARRPI
   181  SISRDWHGYK KKNHTISVGK DINCDVMIHR DDKKEVRAPS PYWIMVKQDN ESSSSSTSST
   241  SDAFWLEDCA QVEEGKAQLV SKVG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDZD9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
10 nTPM

Expression across tissuesHPA

Tissue

  • testis: 10 nTPM
  • cerebellum: 2 nTPM
  • basal ganglia: 1 nTPM
  • cerebral cortex: 0.9 nTPM
  • hypothalamus: 0.6 nTPM
  • amygdala: 0.5 nTPM

Single-cell type

  • late spermatids: 11 nCPM
  • late primary spermatocytes: 5.5 nCPM
  • brain excitatory neurons: 4.8 nCPM
  • brain inhibitory neurons: 4.5 nCPM
  • bergmann glia: 4 nCPM
  • early spermatids: 3.3 nCPM

Immune cell

  • memory B-cell: 0.1 nTPM
  • T-reg: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • cerebellum: 0.2 nTPM
  • cerebral cortex: 0.2 nTPM
  • white matter: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • basal ganglia: 0.1 nTPM
  • hypothalamus: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.24
gnomAD pLI
0
gnomAD missense Z
0.83
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDZD9 as an antibody target. Whether an autoantibody or antibody against PDZD9 could matter depends on whether native PDZD9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDZD9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PDZD9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PDZD9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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