Seroatlas · Human Serome Atlas

PDZD4

PDZ domain-containing protein 4

Also known as: FLJ34125, KIAA1444, LNX5, LU1, PDZD4_HUMAN, PDZK4, PDZRN4L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q76G19
Gene: PDZD4
Ensembl: ENSG00000067840
Chromosome: X
Canonical length: 769 aa
Protein class: Cancer-related genes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in cell cortex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

769 residues, UniProt reviewed canonical sequence.

>Q76G19|PDZD4
     1  MGCNMCVVQK PEEQYKVMLQ VNGKELSKLS QEQTLQALRS SKEPLVIQVL RRSPRLRGDS
    61  SCHDLQLVDS GTQTDITFEH IMALGKLRPP TPPMVILEPP PISHEYYDPA EFMEGGPQEA
   121  DRLDELEYEE VELYKSSHRD KLGLMVCYRT DDEEDLGIYV GEVNPNSIAA KDGRIREGDR
   181  IIQINGVDVQ NREEAVAILS QEENTNISLL VARPESQLAK RWKDSDRDDF LDDFGSENEG
   241  ELRARKLKSP PAQQPGNEEE KGAPDAGPGL SNSQELDSGV GRTDESTRNE ESSEHDLLGD
   301  EPPSSTNTPG SLRKFGLQGD ALQSRDFHFS MDSLLAEGAG LGGGDVPGLT DEEYERYREL
   361  LEIKCHLENG NQLGLLFPRA SGGNSALDVN RNESLGHEMA MLEEELRHLE FKCRNILRAQ
   421  KMQQLRERCM KAWLLEEESL YDLAASEPKK HELSDISELP EKSDKDSTSA YNTGESCRST
   481  PLLVEPLPES PLRRAMAGNS NLNRTPPGPA VATPAKAAPP PGSPAKFRSL SRDPEAGRRQ
   541  HAEERGRRNP KTGLTLERVG PESSPYLSRR HRGQGQEGEH YHSCVQLAPT RGLEELGHGP
   601  LSLAGGPRVG GVAAAATEAP RMEWKVKVRS DGTRYVAKRP VRDRLLKARA LKIREERSGM
   661  TTDDDAVSEM KMGRYWSKEE RKQHLIRARE QRKRREFMMQ SRLECLREQQ NGDSKPELNI
   721  IALSHRKTMK KRNKKILDNW ITIQEMLAHG ARSADGKRVY NPLLSVTTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDZD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 269 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 269 nTPM
hippocampal formation: 240 nTPM
amygdala: 232 nTPM
cerebellum: 203 nTPM
basal ganglia: 184 nTPM
hypothalamus: 80 nTPM

Single-cell type

ependymal cells: 43 nCPM
choroid plexus epithelial cells: 30 nCPM
brain excitatory neurons: 25 nCPM
corticotrophs: 21 nCPM
nk-cells: 20 nCPM
lactotrophs: 20 nCPM

Immune cell

gdT-cell: 0.9 nTPM
memory CD8 T-cell: 0.5 nTPM
memory CD4 T-cell: 0.4 nTPM
NK-cell: 0.4 nTPM
MAIT T-cell: 0.2 nTPM
naive CD8 T-cell: 0.2 nTPM

Brain region

cerebral cortex: 268 nTPM
hippocampal formation: 254 nTPM
amygdala: 184 nTPM
basal ganglia: 177 nTPM
white matter: 162 nTPM
cerebellum: 138 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.4
gnomAD pLI: 0.85
gnomAD missense Z: 2.7
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cell cortex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDZD4 as an antibody target. Whether an autoantibody or antibody against PDZD4 could matter depends on whether native PDZD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDZD4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PDZD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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