Seroatlas · Human Serome Atlas

PDYN

Proenkephalin-B

Also known as: ADCA, PDYN_HUMAN, PENKB, SCA23

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P01213
Gene
PDYN
Ensembl
ENSG00000101327
Chromosome
20
Canonical length
254 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted secreted proteins, Transporters
Secretome location
Secreted in brain

OverviewNCBI Gene

The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]

Canonical amino-acid sequenceUniProt

254 residues, UniProt reviewed canonical sequence.

>P01213|PDYN
     1  MAWQGLVLAA CLLMFPSTTA DCLSRCSLCA VKTQDGPKPI NPLICSLQCQ AALLPSEEWE
    61  RCQSFLSFFT PSTLGLNDKE DLGSKSVGEG PYSELAKLSG SFLKELEKSK FLPSISTKEN
   121  TLSKSLEEKL RGLSDGFREG AESELMRDAQ LNDGAMETGT LYLAEEDPKE QVKRYGGFLR
   181  KYPKRSSEVA GEGDGDSMGH EDLYKRYGGF LRRIRPKLKW DNQKRYGGFL RRQFKVVTRS
   241  QEDPNAYSGE LFDA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDYN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
125 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 125 nTPM
  • cerebral cortex: 46 nTPM
  • hypothalamus: 15 nTPM
  • hippocampal formation: 14 nTPM
  • testis: 10 nTPM
  • amygdala: 9.8 nTPM

Single-cell type

  • late spermatids: 178 nCPM
  • early spermatids: 49 nCPM
  • late primary spermatocytes: 20 nCPM
  • brain inhibitory neurons: 9.5 nCPM
  • brain excitatory neurons: 3.6 nCPM
  • cone photoreceptor cells: 2.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hippocampal formation: 97 nTPM
  • cerebral cortex: 96 nTPM
  • amygdala: 91 nTPM
  • basal ganglia: 68 nTPM
  • spinal cord: 47 nTPM
  • hypothalamus: 40 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PDYN.

Disease | AllUniProt

Conditions PDYN is implicated in, by any mechanism.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 208 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Spinocerebellar ataxia type 23

Disease | ImmuneIEDB

Conditions an epitope on PDYN was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.66
gnomAD pLI
0
gnomAD missense Z
-0.53
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDYN as an antibody target. Whether an autoantibody or antibody against PDYN could matter depends on whether native PDYN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDYN is annotated as secreted, so native PDYN circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PDYN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PDYN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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