Seroatlas · Human Serome Atlas

PDXDC2P

Putative pyridoxal-dependent decarboxylase domain-containing protein 2

Also known as: PDXD2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P474
Gene: PDXDC2P
Canonical length: 469 aa

OverviewNCBI Gene

No narrative summary is available for PDXDC2P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

469 residues, UniProt reviewed canonical sequence.

>Q6P474|PDXDC2P
     1  MDASLEKIAD PTLAEMGKNL KEAVKMLEDS QRRTEEENGK KLISRDIPGP LQGSGQDMVS
    61  ILQLVQNLMH GDEDEEPQSP RIQNIGEQGH VAVLGHSLGA YILTLDEEKL RKLTTRILSD
   121  TTLWLCRIFR YENGCAYFHE EEREGLAKIC RLAIHSQYED FVVDGFSGLY NKKPVIYLSA
   181  AARPGLGQYL CNQLGLPFPC LCRVPCNTMF GSQHQMDVAF LEKLIKDDIE RGRLPLLLVA
   241  NAGTAAVGHT DKIGRLKELC EQYGIWLHVE GVNLATLALG YVSSSVLAAA KCDSMTMTPG
   301  PWLGLPAVPA VTLYKHDPAL TLVAGLISNK PTDKLRALPL WLSLQYLGLD GFVERIKHAC
   361  QLSQWLQESL KKVNYIKILV EDELSSPVVV FRFFQELPGS DPVFKAVPVP NMTPSAVGRE
   421  RHSCDALNLW LGEQLKQLVP ASGLTVMDLE AEGTCLRFSP LMTAAGMIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDXDC2P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31

OntologyGO

Biological processes

carboxylic acid metabolic process

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDXDC2P as an antibody target. Whether an autoantibody or antibody against PDXDC2P could matter depends on whether native PDXDC2P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDXDC2P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PDXDC2P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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