PDPR

Protein identityUniProt · HPA

UniProt accession

Q8NCN5

Gene

PDPR

Ensembl

ENSG00000090857

Chromosome

16

Canonical length

879 aa

Protein class

Metabolic proteins, Predicted intracellular proteins

Subcellular location

Mitochondria

OverviewNCBI Gene

Pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate and links glycolysis to the tricarboxylic acid cycle and fatty acid synthesis. The dephosphorylation and reactivation of PDC is catalyzed by pyruvate dehydrogenase phosphatase (PDP). The dimeric PDP has a catalytic subunit and a regulatory subunit. This gene encodes the FAD-containing regulatory subunit of PDP. The encoded protein acts to decrease the sensitivity of the PDP catalytic subunit to magnesium ions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

879 residues, UniProt reviewed canonical sequence.

>Q8NCN5|PDPR
     1  MMFYRLLSIV GRQRASPGWQ NWSSARNSTS AAEARSMALP TQAQVVICGG GITGTSVAYH
    61  LSKMGWKDIV LLEQGRLAAG STRFCAGILS TARHLTIEQK MADYSNKLYY QLEQETGIQT
   121  GYTRTGSIFL AQTQDRLISL KRINAGLNVI GIPSEIISPK KVAELHHLLN VHDLVGAMHV
   181  PEDAVVSSAD VALALASAAS QNGVQIYDRT SVLHVMVKKG QVTGVETDKG QIECQYFVNC
   241  AGQWAYELGL SNEEPVSIPL HACEHFYLLT RPLETPLQSS TPTIVDADGR IYIRNWQGGI
   301  LSGGFEKNPK PIFTEGKNQL EIQNLQEDWD HFEPLLSSLL RRMPELETLE IMKLVNCPET
   361  FTPDMRCIMG ESPAVQGYFV LAGMNSAGLS FGGGAGKYLA EWMVHGYPSE NVWELDLKRF
   421  GALQSSRTFL RHRVMEVMPL MYDLKVPRWD FQTGRQLRTS PLYDRLDAQG ARWMEKHGFE
   481  RPKYFVPPDK DLLALEQSKT FYKPDWFDIV ESEVKCCKEA VCVIDMSSFT KFEITSTGDQ
   541  ALEVLQYLFS NDLDVPVGHI VHTGMLNEGG GYENDCSIAR LNKRSFFMIS PTDQQVHCWA
   601  WLKKHMPKDS NLLLEDVTWK YTALNLIGPR AVDVLSELSY APMTPDHFPS LFCKEMSVGY
   661  ANGIRVMSMT HTGEPGFMLY IPIEYALHVY NEVMSVGQKY GIRNAGYYAL RSLRIEKFFA
   721  FWGQDINNLT TPLECGRESR VKLEKGMDFI GRDALLQQKQ NGVYKRLTMF ILDDHDSDLD
   781  LWPWWGEPIY RNGQYVGKTT SSAYSYSLER HVCLGFVHNF SEDTGEEQVV TADFINRGEY
   841  EIDIAGYRFQ AKAKLYPVAS LFTQKRRKDD MELSDLHGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDPR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.22

Highest tissue expression

22 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.68

gnomAD pLI

0

gnomAD missense Z

-0.49

DepMap mean gene effect

-0.25

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• positive regulation of pyruvate decarboxylation to acetyl-CoA

Cellular components

• cytoplasm
• mitochondrial matrix
• mitochondrion
• pyruvate dehydrogenase (lipoamide) phosphatase complex

Protein domainsUniProt · Pfam · InterPro

• Rhodanese-like domain
• FAD dependent oxidoreductase
• GCVT, N-terminal domain
• Aminomethyltransferase, C-terminal domain
• Aminomethyltransferase superfamily
• Aminomethyltransferase-like
• Glycine cleavage T-protein/YgfZ, C-terminal
• FAD dependent oxidoreductase, central domain
• FAD/NAD(P)-binding domain superfamily
• FAD dependent oxidoreductase
• GCVT N-terminal domain
• Glycine cleavage T-protein C-terminal barrel domain
• FAD dependent oxidoreductase central domain

KeywordsUniProt

• Mitochondrion
• Transit peptide