Seroatlas · Human Serome Atlas

PDP2

[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

Also known as: KIAA1348, PDP2_HUMAN, PPM2B, PPM2C2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P2J9
Gene: PDP2
Ensembl: ENSG00000172840
Chromosome: 16
Canonical length: 529 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

This gene is a mitochondrial protein that functions as a phosphatase and is involved in the enzymatic resetting of the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

529 residues, UniProt reviewed canonical sequence.

>Q9P2J9|PDP2
     1  MSSTVSYWIL NSTRNSIATL QGGRRLYSRY VSNRNKLKWR LFSRVPPTLN SSPCGGFTLC
    61  KAYRHTSTEE DDFHLQLSPE QINEVLRAGE TTHKILDLES RVPNSVLRFE SNQLAANSPV
   121  EDRRGVASCL QTNGLMFGIF DGHGGHACAQ AVSERLFYYV AVSLMSHQTL EHMEGAMESM
   181  KPLLPILHWL KHPGDSIYKD VTSVHLDHLR VYWQELLDLH MEMGLSIEEA LMYSFQRLDS
   241  DISLEIQAPL EDEVTRNLSL QVAFSGATAC MAHVDGIHLH VANAGDCRAI LGVQEDNGMW
   301  SCLPLTRDHN AWNQAELSRL KREHPESEDR TIIMEDRLLG VLIPCRAFGD VQLKWSKELQ
   361  RSILERGFNT EALNIYQFTP PHYYTPPYLT AEPEVTYHRL RPQDKFLVLA SDGLWDMLSN
   421  EDVVRLVVGH LAEADWHKTD LAQRPANLGL MQSLLLQRKA SGLHEADQNA ATRLIRHAIG
   481  NNEYGEMEAE RLAAMLTLPE DLARMYRDDI TVTVVYFNSE SIGAYYKGG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 8.7 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 8.7 nTPM
kidney: 8.6 nTPM
liver: 8 nTPM
adipose tissue: 5.7 nTPM
parathyroid gland: 5.7 nTPM
duodenum: 5.1 nTPM

Single-cell type

alveolar cells type 2: 34 nCPM
adrenal medulla cells: 32 nCPM
distal convoluted tubule cells: 20 nCPM
parietal cells: 19 nCPM
adipocytes: 19 nCPM
retinal amacrine cells: 18 nCPM

Immune cell

NK-cell: 4.2 nTPM
gdT-cell: 3.8 nTPM
memory CD8 T-cell: 3.2 nTPM
MAIT T-cell: 3.1 nTPM
naive CD8 T-cell: 3 nTPM
naive CD4 T-cell: 2.6 nTPM

Brain region

choroid plexus: 27 nTPM
cerebellum: 24 nTPM
pons: 24 nTPM
thalamus: 22 nTPM
cerebral cortex: 21 nTPM
medulla oblongata: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: 1.3
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

T-helper cell differentiation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDP2 as an antibody target. Whether an autoantibody or antibody against PDP2 could matter depends on whether native PDP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PDP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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