PDLIM3

Protein identityUniProt · HPA

UniProt accession

Q53GG5

Gene

PDLIM3

Ensembl

ENSG00000154553

Chromosome

4

Canonical length

364 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Cytosol

OverviewNCBI Gene

The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy. [provided by RefSeq, Apr 2012]

Canonical amino-acid sequenceUniProt

364 residues, UniProt reviewed canonical sequence.

>Q53GG5|PDLIM3
     1  MPQTVILPGP APWGFRLSGG IDFNQPLVIT RITPGSKAAA ANLCPGDVIL AIDGFGTESM
    61  THADAQDRIK AAAHQLCLKI DRGETHLWSP QVSEDGKAHP FKINLESEPQ DGNYFEHKHN
   121  IRPKPFVIPG RSSGCSTPSG IDCGSGRSTP SSVSTVSTIC PGDLKVAAKL APNIPLEMEL
   181  PGVKIVHAQF NTPMQLYSDD NIMETLQGQV STALGETPLM SEPTASVPPE SDVYRMLHDN
   241  RNEPTQPRQS GSFRVLQGMV DDGSDDRPAG TRSVRAPVTK VHGGSGGAQR MPLCDKCGSG
   301  IVGAVVKARD KYRHPECFVC ADCNLNLKQK GYFFIEGELY CETHARARTK PPEGYDTVTL
   361  YPKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDLIM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.51

Highest tissue expression

3,109 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.22

gnomAD pLI

0

gnomAD missense Z

-0.02

DepMap mean gene effect

0.14

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• actin cytoskeleton organization
• actin filament organization
• heart development
• muscle structure development

Molecular functions

• actin binding
• metal ion binding
• muscle alpha-actinin binding
• structural constituent of muscle

Cellular components

• adherens junction
• cytosol
• filamentous actin
• stress fiber
• Z disc

Protein domainsUniProt · Pfam · InterPro

• PDZ domain
• Zinc finger, LIM-type
• Zasp-like motif
• PDZ and LIM domain protein 1-4/Zasp-like, middle domain
• PDZ superfamily
• PDZ and LIM domain-containing
• LIM domain
• PDZ domain
• Domain of unknown function (DUF4749)

KeywordsUniProt

• Cytoplasm
• LIM domain
• Metal-binding
• Phosphoprotein
• Zinc

InteractionsUniProt · HPA

Protein binding partners of PDLIM3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ACTN2