Seroatlas · Human Serome Atlas

PDGFRL

Platelet-derived growth factor receptor-like protein

Also known as: PGFRL_HUMAN, PRLTS

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15198
Gene: PDGFRL
Ensembl: ENSG00000104213
Chromosome: 8
Canonical length: 375 aa
Protein class: Disease related genes, Potential drug targets, Predicted secreted proteins, Transporters
Subcellular location: Nucleoplasm,Nucleoli,Golgi apparatus
Secretome location: Secreted - unknown location

OverviewNCBI Gene

This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

375 residues, UniProt reviewed canonical sequence.

>Q15198|PDGFRL
     1  MKVWLLLGLL LVHEALEDVT GQHLPKNKRP KEPGENRIKP TNKKVKPKIP KMKDRDSANS
    61  APKTQSIMMQ VLDKGRFQKP AATLSLLAGQ TVELRCKGSR IGWSYPAYLD TFKDSRLSVK
   121  QNERYGQLTL VNSTSADTGE FSCWVQLCSG YICRKDEAKT GSTYIFFTEK GELFVPSPSY
   181  FDVVYLNPDR QAVVPCRVTV LSAKVTLHRE FPAKEIPANG TDIVYDMKRG FVYLQPHSEH
   241  QGVVYCRAEA GGRSQISVKY QLLYVAVPSG PPSTTILASS NKVKSGDDIS VLCTVLGEPD
   301  VEVEFTWIFP GQKDERPVTI QDTWRLIHRG LGHTTRISQS VITVEDFETI DAGYYICTAQ
   361  NLQGQTTVAT TVEFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDGFRL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 62 nTPM

Expression across tissuesHPA

Tissue

ovary: 62 nTPM
breast: 50 nTPM
adipose tissue: 37 nTPM
tongue: 35 nTPM
thyroid gland: 31 nTPM
cervix: 26 nTPM

Single-cell type

oocytes: 318 nCPM
fibroblasts: 142 nCPM
fibro-adipogenic progenitors: 108 nCPM
leydig cells: 76 nCPM
cardiomyocytes: 71 nCPM
peritubular myoid cells: 70 nCPM

Immune cell

classical monocyte: 0.3 nTPM
neutrophil: 0.2 nTPM
myeloid DC: 0.1 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

basal ganglia: 5.4 nTPM
white matter: 4.8 nTPM
hypothalamus: 4.2 nTPM
cerebellum: 4.1 nTPM
thalamus: 4 nTPM
medulla oblongata: 3.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PDGFRL.

Disease | AllUniProt

Conditions PDGFRL is implicated in, by any mechanism.

Colorectal cancer (CRC) MIM:114500

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 104 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Carcinoma of colon

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.8
gnomAD pLI: 0
gnomAD missense Z: -2
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

Immunoglobulin subtype 2
Immunoglobulin domain subtype
Immunoglobulin-like domain
Immunoglobulin-like fold
Immunoglobulin-like domain superfamily
Immunoglobulin domain
Vascular endothelial growth factor receptor 1-like, Ig-like domain
Platelet-derived growth factor receptor-like protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDGFRL as an antibody target. Whether an autoantibody or antibody against PDGFRL could matter depends on whether native PDGFRL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDGFRL is annotated as secreted, so native PDGFRL circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PDGFRL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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