Seroatlas · Human Serome Atlas

PDGFD

Platelet-derived growth factor D

Also known as: IEGF, MSTP036, PDGFD_HUMAN, SCDGF-B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9GZP0
Gene
PDGFD
Ensembl
ENSG00000170962
Chromosome
11
Canonical length
370 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins
Subcellular location
Golgi apparatus,Vesicles
Secretome location
Secreted to blood
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

370 residues, UniProt reviewed canonical sequence.

>Q9GZP0|PDGFD
     1  MHRLIFVYTL ICANFCSCRD TSATPQSASI KALRNANLRR DESNHLTDLY RRDETIQVKG
    61  NGYVQSPRFP NSYPRNLLLT WRLHSQENTR IQLVFDNQFG LEEAENDICR YDFVEVEDIS
   121  ETSTIIRGRW CGHKEVPPRI KSRTNQIKIT FKSDDYFVAK PGFKIYYSLL EDFQPAAASE
   181  TNWESVTSSI SGVSYNSPSV TDPTLIADAL DKKIAEFDTV EDLLKYFNPE SWQEDLENMY
   241  LDTPRYRGRS YHDRKSKVDL DRLNDDAKRY SCTPRNYSVN IREELKLANV VFFPRCLLVQ
   301  RCGGNCGCGT VNWRSCTCNS GKTVKKYHEV LQFEPGHIKR RGRAKTMALV DIQLDHHERC
   361  DCICSSRPPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDGFD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
101 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 101 nTPM
  • blood vessel: 67 nTPM
  • ovary: 61 nTPM
  • seminal vesicle: 35 nTPM
  • gallbladder: 32 nTPM
  • pancreas: 24 nTPM

Single-cell type

  • adrenal cortex cells: 2,192 nCPM
  • pituitary stem cells: 2,084 nCPM
  • pancreatic duct cells: 498 nCPM
  • thyrotrophs: 491 nCPM
  • nk-cells: 390 nCPM
  • somatotrophs: 346 nCPM

Immune cell

  • NK-cell: 17 nTPM
  • gdT-cell: 16 nTPM
  • eosinophil: 9.5 nTPM
  • memory CD8 T-cell: 7.2 nTPM
  • naive CD8 T-cell: 6 nTPM
  • total PBMC: 4.2 nTPM

Brain region

  • choroid plexus: 21 nTPM
  • pons: 21 nTPM
  • midbrain: 14 nTPM
  • medulla oblongata: 12 nTPM
  • white matter: 5.6 nTPM
  • hypothalamus: 5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.73
gnomAD pLI
0
gnomAD missense Z
0.34
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PDGFD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDGFD as an antibody target. Whether an autoantibody or antibody against PDGFD could matter depends on whether native PDGFD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDGFD is annotated as secreted, so native PDGFD circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PDGFD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PDGFD. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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