Seroatlas · Human Serome Atlas

PDGFC

Platelet-derived growth factor C

Also known as: fallotein, PDGFC_HUMAN, SCDGF

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NRA1
Gene
PDGFC
Ensembl
ENSG00000145431
Chromosome
4
Canonical length
345 aa
Protein class
Predicted secreted proteins, RAS pathway related proteins
Subcellular location
Plasma membrane,Cytosol
Secretome location
Secreted to blood
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

345 residues, UniProt reviewed canonical sequence.

>Q9NRA1|PDGFC
     1  MSLFGLLLLT SALAGQRQGT QAESNLSSKF QFSSNKEQNG VQDPQHERII TVSTNGSIHS
    61  PRFPHTYPRN TVLVWRLVAV EENVWIQLTF DERFGLEDPE DDICKYDFVE VEEPSDGTIL
   121  GRWCGSGTVP GKQISKGNQI RIRFVSDEYF PSEPGFCIHY NIVMPQFTEA VSPSVLPPSA
   181  LPLDLLNNAI TAFSTLEDLI RYLEPERWQL DLEDLYRPTW QLLGKAFVFG RKSRVVDLNL
   241  LTEEVRLYSC TPRNFSVSIR EELKRTDTIF WPGCLLVKRC GGNCACCLHN CNECQCVPSK
   301  VTKKYHEVLQ LRPKTGVRGL HKSLTDVALE HHEECDCVCR GSTGG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDGFC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
19 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 19 nTPM
  • ovary: 11 nTPM
  • endometrium: 9.3 nTPM
  • smooth muscle: 8.8 nTPM
  • cervix: 8.6 nTPM
  • prostate: 8.1 nTPM

Single-cell type

  • salivary acinar cells: 480 nCPM
  • proximal tubule cells: 410 nCPM
  • macrophages: 387 nCPM
  • medullary thymic epithelial cells: 365 nCPM
  • salivary myoepithelial cells: 300 nCPM
  • kupffer cells: 297 nCPM

Immune cell

  • classical monocyte: 0.4 nTPM
  • non-classical monocyte: 0.2 nTPM
  • intermediate monocyte: 0.1 nTPM
  • total PBMC: 0.1 nTPM
  • basophil: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • hypothalamus: 3.9 nTPM
  • basal ganglia: 3.7 nTPM
  • hippocampal formation: 3.7 nTPM
  • white matter: 3.7 nTPM
  • cerebral cortex: 3.5 nTPM
  • spinal cord: 3.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.2
gnomAD pLI
0.99
gnomAD missense Z
1.17
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PDGFC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDGFC as an antibody target. Whether an autoantibody or antibody against PDGFC could matter depends on whether native PDGFC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDGFC is annotated at the cell surface, where native PDGFC is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PDGFC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PDGFC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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