PDGFA
Platelet-derived growth factor subunit A
Also known as: PDGF-A, PDGF1, PDGFA_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P04085
- Gene
- PDGFA
- Ensembl
- ENSG00000197461
- Chromosome
- 7
- Canonical length
- 211 aa
- Protein class
- Cancer-related genes, Candidate cardiovascular disease genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins
- Subcellular location
- Golgi apparatus
- Secretome location
- Secreted to blood
- Quaternary structure
- Homodimer
OverviewNCBI Gene
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Canonical amino-acid sequenceUniProt
211 residues, UniProt reviewed canonical sequence.
>P04085|PDGFA
1 MRTLACLLLL GCGYLAHVLA EEAEIPREVI ERLARSQIHS IRDLQRLLEI DSVGSEDSLD
61 TSLRAHGVHA TKHVPEKRPL PIRRKRSIEE AVPAVCKTRT VIYEIPRSQV DPTSANFLIW
121 PPCVEVKRCT GCCNTSSVKC QPSRVHHRSV KVAKVEYVRK KPKLKEVQVR LEEHLECACA
181 TTSLNPDYRE EDTGRPRESG KKRKRKRLKP TLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PDGFA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.51
- Highest tissue expression
- 102 nTPM
Expression across tissuesHPA
Tissue
- blood vessel: 102 nTPM
- skeletal muscle: 75 nTPM
- pancreas: 69 nTPM
- spinal cord: 45 nTPM
- stomach: 31 nTPM
- colon: 28 nTPM
Single-cell type
- platelets: 610 nCPM
- pancreatic acinar cells: 400 nCPM
- breast myoepithelial cells: 382 nCPM
- vascular smooth muscle cells: 193 nCPM
- schwann cells: 156 nCPM
- alveolar cells type 1: 139 nCPM
Immune cell
- basophil: 9.5 nTPM
- neutrophil: 4.3 nTPM
- NK-cell: 2.9 nTPM
- non-classical monocyte: 2.8 nTPM
- eosinophil: 2 nTPM
- MAIT T-cell: 1.8 nTPM
Brain region
- white matter: 117 nTPM
- medulla oblongata: 99 nTPM
- pons: 81 nTPM
- midbrain: 78 nTPM
- cerebellum: 77 nTPM
- spinal cord: 77 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.48
- gnomAD pLI
- 0.81
- gnomAD missense Z
- 0.69
- DepMap mean gene effect
- -0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- actin cytoskeleton organization
- angiogenesis
- animal organ morphogenesis
- bone development
- cell activation
- cell population proliferation
- cell projection assembly
- cell-cell signaling
- digestive tract development
- embryonic lung development
- hair follicle development
- lung alveolus development
- negative chemotaxis
- negative regulation of phosphatidylinositol biosynthetic process
- negative regulation of platelet activation
- platelet-derived growth factor receptor signaling pathway
- platelet-derived growth factor receptor-alpha signaling pathway
- positive regulation of cell division
- positive regulation of cell migration
- positive regulation of cell population proliferation
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of fibroblast proliferation
- positive regulation of MAPK cascade
- positive regulation of mesenchymal cell proliferation
- positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
- positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
- regulation of actin cytoskeleton organization
- regulation of smooth muscle cell migration
- response to wounding
- skin development
- wound healing
- regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling
Molecular functions
- collagen binding
- growth factor activity
- identical protein binding
- platelet-derived growth factor binding
- platelet-derived growth factor receptor binding
- protein heterodimerization activity
- protein homodimerization activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of PDGFA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PDGFA as an antibody target. Whether an autoantibody or antibody against PDGFA could matter depends on whether native PDGFA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PDGFA is annotated as secreted, so native PDGFA circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label PDGFA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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