Seroatlas · Human Serome Atlas

PDCD7

Programmed cell death protein 7

Also known as: 59K, ES18, HES18, PDCD7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N8D1
Gene
PDCD7
Ensembl
ENSG00000090470
Chromosome
15
Canonical length
485 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli,Plasma membrane

OverviewNCBI Gene

This gene encodes a 59 kDa protein that is associated with the U11 small nuclear ribonucleoprotein (snRNP), which is a component of the minor U12-type spliceosome responsible for catalyzing pre-mRNA splicing of U12-type introns. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

485 residues, UniProt reviewed canonical sequence.

>Q8N8D1|PDCD7
     1  MALPPFFGQG RPGPPPPQPP PPAPFGCPPP PLPSPAFPPP LPQRPGPFPG ASAPFLQPPL
    61  ALQPRASAEA SRGGGGAGAF YPVPPPPLPP PPPQCRPFPG TDAGERPRPP PPGPGPPWSP
   121  RWPEAPPPPA DVLGDAALQR LRDRQWLEAV FGTPRRAGCP VPQRTHAGPS LGEVRARLLR
   181  ALRLVRRLRG LSQALREAEA DGAAWVLLYS QTAPLRAELA ERLQPLTQAA YVGEARRRLE
   241  RVRRRRLRLR ERAREREAER EAEAARAVER EQEIDRWRVK CVQEVEEKKR EQELKAAADG
   301  VLSEVRKKQA DTKRMVDILR ALEKLRKLRK EAAARKGVCP PASADETFTH HLQRLRKLIK
   361  KRSELYEAEE RALRVMLEGE QEEERKRELE KKQRKEKEKI LLQKREIESK LFGDPDEFPL
   421  AHLLEPFRQY YLQAEHSLPA LIQIRHDWDQ YLVPSDHPKG NFVPQGWVLP PLPSNDIWAT
   481  AVKLH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDCD7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • testis: 18 nTPM
  • esophagus: 17 nTPM
  • ovary: 17 nTPM
  • endometrium: 16 nTPM
  • cervix: 15 nTPM
  • colon: 15 nTPM

Single-cell type

  • early primary spermatocytes: 191 nCPM
  • retinal bipolar cells: 123 nCPM
  • esophageal apical cells: 104 nCPM
  • rod photoreceptor cells: 97 nCPM
  • cone photoreceptor cells: 93 nCPM
  • undifferentiated spermatogonia: 91 nCPM

Immune cell

  • NK-cell: 3.3 nTPM
  • naive B-cell: 2.4 nTPM
  • memory B-cell: 2.3 nTPM
  • basophil: 2.1 nTPM
  • gdT-cell: 2 nTPM
  • naive CD4 T-cell: 2 nTPM

Brain region

  • cerebellum: 39 nTPM
  • cerebral cortex: 36 nTPM
  • white matter: 36 nTPM
  • pons: 32 nTPM
  • medulla oblongata: 32 nTPM
  • thalamus: 31 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PDCD7.

Disease | ImmuneIEDB

Conditions an epitope on PDCD7 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.12
gnomAD pLI
0
gnomAD missense Z
0.75
DepMap mean gene effect
-0.88
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Programmed cell death protein 7
  • Apoptosis-promoting protein
  • Programmed cell death protein 7

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PDCD7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDCD7 as an antibody target. Whether an autoantibody or antibody against PDCD7 could matter depends on whether native PDCD7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDCD7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PDCD7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PDCD7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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