Seroatlas · Human Serome Atlas

PDCD1LG2

Programmed cell death 1 ligand 2

Also known as: B7-DC, bA574F11.2, Btdc, CD273, PD-L2, PD1L2_HUMAN, PDL2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BQ51
Gene: PDCD1LG2
Ensembl: ENSG00000197646
Chromosome: 9
Canonical length: 273 aa
Protein class: Cancer-related genes, CD markers, Predicted membrane proteins, Predicted secreted proteins
Subcellular location: Cytosol
Secretome location: Secreted - unknown location

OverviewNCBI Gene

Involved in negative regulation of activated T cell proliferation; negative regulation of interleukin-10 production; and negative regulation of type II interferon production. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of pulmonary tuberculosis. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

273 residues, UniProt reviewed canonical sequence.

>Q9BQ51|PDCD1LG2
     1  MIFLLLMLSL ELQLHQIAAL FTVTVPKELY IIEHGSNVTL ECNFDTGSHV NLGAITASLQ
    61  KVENDTSPHR ERATLLEEQL PLGKASFHIP QVQVRDEGQY QCIIIYGVAW DYKYLTLKVK
   121  ASYRKINTHI LKVPETDEVE LTCQATGYPL AEVSWPNVSV PANTSHSRTP EGLYQVTSVL
   181  RLKPPPGRNF SCVFWNTHVR ELTLASIDLQ SQMEPRTHPT WLLHIFIPFC IIAFIFIATV
   241  IALRKQLCQK LYSSKDTTKR PVTTTKREVN SAI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDCD1LG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

spleen: 14 nTPM
lymph node: 9.7 nTPM
lung: 6.7 nTPM
appendix: 6.5 nTPM
tonsil: 5.8 nTPM
thymus: 4.7 nTPM

Single-cell type

extravillous trophoblasts: 55 nCPM
adipocytes: 46 nCPM
mast cells: 42 nCPM
fibro-adipogenic progenitors: 31 nCPM
microglia: 31 nCPM
cdc: 21 nCPM

Immune cell

basophil: 1.5 nTPM
intermediate monocyte: 1.4 nTPM
T-reg: 1.2 nTPM
memory CD4 T-cell: 0.7 nTPM
neutrophil: 0.7 nTPM
MAIT T-cell: 0.6 nTPM

Brain region

white matter: 3.4 nTPM
medulla oblongata: 3.3 nTPM
pons: 3 nTPM
spinal cord: 2.7 nTPM
hypothalamus: 2.6 nTPM
thalamus: 2.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0
gnomAD missense Z: -0.67
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

receptor ligand activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDCD1LG2 as an antibody target. Whether an autoantibody or antibody against PDCD1LG2 could matter depends on whether native PDCD1LG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDCD1LG2 is annotated at the cell surface, where native PDCD1LG2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PDCD1LG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...