Seroatlas · Human Serome Atlas

PCSK1N

ProSAAS

Also known as: BigLEN, PCS1N_HUMAN, PEN, proSAAS, SAAS, SCG8, SgVIII

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UHG2
Gene: PCSK1N
Ensembl: ENSG00000102109
Chromosome: X
Canonical length: 260 aa
Protein class: Predicted secreted proteins
Subcellular location: Vesicles
Secretome location: Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene functions as an inhibitor of prohormone convertase 1, which regulates the proteolytic cleavage of neuroendocrine peptide precursors. The proprotein is further processed into multiple short peptides. A polymorphism within this gene may be associated with obesity. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

260 residues, UniProt reviewed canonical sequence.

>Q9UHG2|PCSK1N
     1  MAGSPLLWGP RAGGVGLLVL LLLGLFRPPP ALCARPVKEP RGLSAASPPL AETGAPRRFR
    61  RSVPRGEAAG AVQELARALA HLLEAERQER ARAEAQEAED QQARVLAQLL RVWGAPRNSD
   121  PALGLDDDPD APAAQLARAL LRARLDPAAL AAQLVPAPVP AAALRPRPPV YDDGPAGPDA
   181  EEAGDETPDV DPELLRYLLG RILAGSADSE GVAAPRRLRR AADHDVGSEL PPEGVLGALL
   241  RVKRLETPAP QVPARRLLPP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCSK1N can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 1,213 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 1,213 nTPM
hypothalamus: 783 nTPM
basal ganglia: 737 nTPM
cerebral cortex: 560 nTPM
amygdala: 505 nTPM
hippocampal formation: 422 nTPM

Single-cell type

neuroendocrine cells: 4,146 nCPM
pancreatic islet cells: 2,847 nCPM
epididymal efferent duct ciliated cells: 1,181 nCPM
corticotrophs: 1,038 nCPM
gonadotrophs: 898 nCPM
other brain neurons: 886 nCPM

Immune cell

naive CD8 T-cell: 6.4 nTPM
memory CD4 T-cell: 5 nTPM
memory CD8 T-cell: 4.9 nTPM
MAIT T-cell: 2.4 nTPM
naive CD4 T-cell: 2 nTPM
T-reg: 1.8 nTPM

Brain region

hypothalamus: 1,741 nTPM
medulla oblongata: 991 nTPM
midbrain: 939 nTPM
cerebral cortex: 814 nTPM
pons: 803 nTPM
amygdala: 758 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0.53
gnomAD missense Z: 0.81
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

ProSAAS
ProSAAS precursor

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCSK1N as an antibody target. Whether an autoantibody or antibody against PCSK1N could matter depends on whether native PCSK1N is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCSK1N is annotated as secreted, so native PCSK1N circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PCSK1N as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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