Seroatlas · Human Serome Atlas

PCP4L1

Purkinje cell protein 4-like protein 1

Also known as: IQM1, PC4L1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NKN8
Gene
PCP4L1
Ensembl
ENSG00000248485
Chromosome
1
Canonical length
68 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Mitochondria

OverviewNCBI Gene

No narrative summary is available for PCP4L1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

68 residues, UniProt reviewed canonical sequence.

>A6NKN8|PCP4L1
     1  MSELNTKTSP ATNQAAGQEE KGKAGNVKKA EEEEEIDIDL TAPETEKAAL AIQGKFRRFQ
    61  KRKKDPSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCP4L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
191 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 191 nTPM
  • pituitary gland: 87 nTPM
  • retina: 36 nTPM
  • cerebral cortex: 36 nTPM
  • urinary bladder: 33 nTPM
  • hypothalamus: 23 nTPM

Single-cell type

  • retinal bipolar cells: 100 nCPM
  • respiratory basal cells: 62 nCPM
  • urothelial cells: 62 nCPM
  • ocular epithelial cells: 61 nCPM
  • basal prostatic cells: 56 nCPM
  • brain inhibitory neurons: 46 nCPM

Immune cell

  • T-reg: 0.8 nTPM
  • myeloid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • basal ganglia: 154 nTPM
  • pons: 87 nTPM
  • medulla oblongata: 71 nTPM
  • spinal cord: 64 nTPM
  • midbrain: 51 nTPM
  • cerebral cortex: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.64
gnomAD pLI
0.05
gnomAD missense Z
0.08
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCP4L1 as an antibody target. Whether an autoantibody or antibody against PCP4L1 could matter depends on whether native PCP4L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCP4L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PCP4L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PCP4L1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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