Seroatlas · Human Serome Atlas

PCOTH

Prostate collagen triple helix protein

Also known as: PCOTH_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q58A44
Gene: PCOTH
Canonical length: 107 aa

OverviewNCBI Gene

No narrative summary is available for PCOTH in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

107 residues, UniProt reviewed canonical sequence.

>Q58A44|PCOTH
     1  MWILSNLMGT SEEGNLLSTV SPTVKALFGK TRVSPIFPFS PRSPFQPLIP RTPGSPWGPV
    61  GPASPLGPGF PIGPMGPGKP VGPKGPMLPL GPSGPVGPTS PLFPFCP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCOTH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71

OntologyGO

Cellular components

cytoplasm

KeywordsUniProt

Cytoplasm

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCOTH as an antibody target. Whether an autoantibody or antibody against PCOTH could matter depends on whether native PCOTH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCOTH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PCOTH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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