Seroatlas · Human Serome Atlas

PCOLCE2

Procollagen C-endopeptidase enhancer 2

Also known as: PCOC2_HUMAN, PCPE2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UKZ9
Gene: PCOLCE2
Ensembl: ENSG00000163710
Chromosome: 3
Canonical length: 415 aa
Protein class: Predicted secreted proteins
Subcellular location: Nucleoplasm,Cytosol
Secretome location: Secreted to extracellular matrix

OverviewNCBI Gene

Enables collagen binding activity; heparin binding activity; and peptidase activator activity. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in extracellular region. Predicted to be part of collagen trimer. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

415 residues, UniProt reviewed canonical sequence.

>Q9UKZ9|PCOLCE2
     1  MRGANAWAPL CLLLAAATQL SRQQSPERPV FTCGGILTGE SGFIGSEGFP GVYPPNSKCT
    61  WKITVPEGKV VVLNFRFIDL ESDNLCRYDF VDVYNGHANG QRIGRFCGTF RPGALVSSGN
   121  KMMVQMISDA NTAGNGFMAM FSAAEPNERG DQYCGGLLDR PSGSFKTPNW PDRDYPAGVT
   181  CVWHIVAPKN QLIELKFEKF DVERDNYCRY DYVAVFNGGE VNDARRIGKY CGDSPPAPIV
   241  SERNELLIQF LSDLSLTADG FIGHYIFRPK KLPTTTEQPV TTTFPVTTGL KPTVALCQQK
   301  CRRTGTLEGN YCSSDFVLAG TVITTITRDG SLHATVSIIN IYKEGNLAIQ QAGKNMSARL
   361  TVVCKQCPLL RRGLNYIIMG QVGEDGRGKI MPNSFIMMFK TKNQKLLDAL KNKQC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCOLCE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 136 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 136 nTPM
adipose tissue: 82 nTPM
blood vessel: 82 nTPM
placenta: 45 nTPM
breast: 32 nTPM
urinary bladder: 30 nTPM

Single-cell type

corticotrophs: 661 nCPM
podocytes: 521 nCPM
adipocytes: 432 nCPM
syncytiotrophoblasts: 383 nCPM
cytotrophoblasts: 216 nCPM
fibroblasts: 207 nCPM

Immune cell

neutrophil: 0.3 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

hypothalamus: 3.9 nTPM
thalamus: 3 nTPM
cerebral cortex: 2.4 nTPM
midbrain: 2 nTPM
basal ganglia: 1.4 nTPM
choroid plexus: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: 0.59
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cellular response to leukemia inhibitory factor

Molecular functions

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCOLCE2 as an antibody target. Whether an autoantibody or antibody against PCOLCE2 could matter depends on whether native PCOLCE2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCOLCE2 is annotated as secreted, so native PCOLCE2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PCOLCE2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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