Seroatlas · Human Serome Atlas

PCOLCE

Procollagen C-endopeptidase enhancer 1

Also known as: PCOC1_HUMAN, PCPE, PCPE1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15113
Gene: PCOLCE
Ensembl: ENSG00000106333
Chromosome: 7
Canonical length: 449 aa
Protein class: Plasma proteins, Predicted secreted proteins
Subcellular location: Golgi apparatus,Vesicles
Secretome location: Secreted to extracellular matrix

OverviewNCBI Gene

Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

449 residues, UniProt reviewed canonical sequence.

>Q15113|PCOLCE
     1  MLPAATASLL GPLLTACALL PFAQGQTPNY TRPVFLCGGD VKGESGYVAS EGFPNLYPPN
    61  KECIWTITVP EGQTVSLSFR VFDLELHPAC RYDALEVFAG SGTSGQRLGR FCGTFRPAPL
   121  VAPGNQVTLR MTTDEGTGGR GFLLWYSGRA TSGTEHQFCG GRLEKAQGTL TTPNWPESDY
   181  PPGISCSWHI IAPPDQVIAL TFEKFDLEPD TYCRYDSVSV FNGAVSDDSR RLGKFCGDAV
   241  PGSISSEGNE LLVQFVSDLS VTADGFSASY KTLPRGTAKE GQGPGPKRGT EPKVKLPPKS
   301  QPPEKTEESP SAPDAPTCPK QCRRTGTLQS NFCASSLVVT ATVKSMVREP GEGLAVTVSL
   361  IGAYKTGGLD LPSPPTGASL KFYVPCKQCP PMKKGVSYLL MGQVEENRGP VLPPESFVVL
   421  HRPNQDQILT NLSKRKCPSQ PVRAAASQD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCOLCE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 180 nTPM

Expression across tissuesHPA

Tissue

cervix: 180 nTPM
heart muscle: 131 nTPM
blood vessel: 110 nTPM
gallbladder: 105 nTPM
adipose tissue: 104 nTPM
endometrium: 102 nTPM

Single-cell type

decidual stromal cells: 2,746 nCPM
hepatic stellate cells: 491 nCPM
fibroblasts: 363 nCPM
endometrial stromal cells: 359 nCPM
pericytes: 146 nCPM
leydig cells: 126 nCPM

Immune cell

eosinophil: 0.4 nTPM
NK-cell: 0.4 nTPM
intermediate monocyte: 0.3 nTPM
MAIT T-cell: 0.3 nTPM
memory CD4 T-cell: 0.2 nTPM
myeloid DC: 0.2 nTPM

Brain region

choroid plexus: 6.7 nTPM
cerebral cortex: 6.4 nTPM
thalamus: 4.7 nTPM
basal ganglia: 4.4 nTPM
cerebellum: 4.2 nTPM
spinal cord: 3.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0
gnomAD missense Z: 0.16
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PCOLCE in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

EFEMP2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCOLCE as an antibody target. Whether an autoantibody or antibody against PCOLCE could matter depends on whether native PCOLCE is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCOLCE is annotated as secreted, so native PCOLCE circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PCOLCE as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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