Seroatlas · Human Serome Atlas

PCNX4

Pecanex-like protein 4

Also known as: C14orf135, PCNXL4, PCX4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q63HM2
Gene: PCNX4
Ensembl: ENSG00000126773
Chromosome: 14
Canonical length: 1172 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1172 residues, UniProt reviewed canonical sequence.

>Q63HM2|PCNX4
     1  MSPDVPLLND YKQDFFLKRF PQTVLGGPRF KLGYCAPPYI YVNQIILFLM PWVWGGVGTL
    61  LYQLGILKDY YTAALSGGLM LFTAFVIQFT SLYAKNKSTT VERILTTDIL AEEDEHEFTS
   121  CTGAETVKFL IPGKKYVANT VFHSILAGLA CGLGTWYLLP NRITLLYGST GGTALLFFFG
   181  WMTLCIAEYS LIVNTATETA TFQTQDTYEI IPLMRPLYIF FFVSVDLAHR FVVNMPALEH
   241  MNQILHILFV FLPFLWALGT LPPPDALLLW AMEQVLEFGL GGSSMSTHLR LLVMFIMSAG
   301  TAIASYFIPS TVGVVLFMTG FGFLLSLNLS DMGHKIGTKS KDLPSGPEKH FSWKECLFYI
   361  IILVLALLET SLLHHFAGFS QISKSNSQAI VGYGLMILLI ILWILREIQS VYIIGIFRNP
   421  FYPKDVQTVT VFFEKQTRLM KIGIVRRILL TLVSPFAMIA FLSLDSSLQG LHSVSVCIGF
   481  TRAFRMVWQN TENALLETVI VSTVHLISST DIWWNRSLDT GLRLLLVGII RDRLIQFISK
   541  LQFAVTVLLT SWTEKKQRRK TTATLCILNI VFSPFVLVII VFSTLLSSPL LPLFTLPVFL
   601  VGFPRPIQSW PGAAGTTACV CADTVYYYQM VPRLTAVLQT AMAAGSLGLL LPGSHYLGRF
   661  QDRLMWIMIL ECGYTYCSIN IKGLELQETS CHTAEARRVD EVFEDAFEQE YTRVCSLNEH
   721  FGNVLTPCTV LPVKLYSDAR NVLSGIIDSH ENLKEFKGDL IKVLVWILVQ YCSKRPGMKE
   781  NVHNTENKGK APLMLPALNT LPPPKSPEDI DSLNSETFND WSDDNIFDDE PTIKKVIEEK
   841  HQLKDLPGTN LFIPGSVESQ RVGDHSTGTV PENDLYKAVL LGYPAVDKGK QEDMPYIPLM
   901  EFSCSHSHLV CLPAEWRTSC MPSSKMKEMS SLFPEDWYQF VLRQLECYHS EEKASNVLEE
   961  IAKDKVLKDF YVHTVMTCYF SLFGIDNMAP SPGHILRVYG GVLPWSVALD WLTEKPELFQ
  1021  LALKAFRYTL KLMIDKASLG PIEDFRELIK YLEEYERDWY IGLVSDEKWK EAILQEKPYL
  1081  FSLGYDSNMG IYTGRVLSLQ ELLIQVGKLN PEAVRGQWAN LSWELLYATN DDEERYSIQA
  1141  HPLLLRNLTV QAAEPPLGYP IYSSKPLHIH LY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCNX4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 15
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

retina: 17 nTPM
fallopian tube: 12 nTPM
endometrium: 12 nTPM
kidney: 12 nTPM
ovary: 11 nTPM
prostate: 11 nTPM

Single-cell type

renal collecting duct intercalated cells: 416 nCPM
cardiomyocytes: 363 nCPM
choroid plexus epithelial cells: 309 nCPM
endometrial ciliated cells: 303 nCPM
somatotrophs: 297 nCPM
lactotrophs: 288 nCPM

Immune cell

NK-cell: 8.4 nTPM
MAIT T-cell: 6.5 nTPM
non-classical monocyte: 5.3 nTPM
gdT-cell: 4.8 nTPM
myeloid DC: 4.4 nTPM
naive CD8 T-cell: 4.4 nTPM

Brain region

choroid plexus: 38 nTPM
cerebellum: 26 nTPM
hypothalamus: 25 nTPM
midbrain: 25 nTPM
white matter: 24 nTPM
medulla oblongata: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCNX4 as an antibody target. Whether an autoantibody or antibody against PCNX4 could matter depends on whether native PCNX4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCNX4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PCNX4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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