Seroatlas · Human Serome Atlas

PCNX3

Pecanex-like protein 3

Also known as: FLJ22427, PCNXL3, PCX3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H6A9
Gene: PCNX3
Ensembl: ENSG00000197136
Chromosome: 11
Canonical length: 2034 aa
Protein class: Predicted membrane proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

2034 residues, UniProt reviewed canonical sequence.

>Q9H6A9|PCNX3
     1  MGSQVLQILR QGVWASLTGG WFFDPHQSTF SNCFHLYVWI FLLIFPFLLY MVLPPSLMVA
    61  GVYCLVVAVI FATIKTVNYR LHAMFDQGEI VEKRSSTMGE LEEEPAQGDS NPPRDPGVEM
   121  TVFRKVSSTP PVRCSSQHSV FGFNQVSELL PRMEDSGPLR DIKELVREQG SNNVIVTSAD
   181  REMLKLSSQE KLIGDLPQTP PGAVPDPSLA STDSSEPSPL AGDGAPWSGS SMADTPMSPL
   241  LKGSLSQELS KSFLTLTQPD RALVRTSSRR EQRRGAGGYQ PLDRRGSGEP TPQKAGSSDS
   301  CFSGTDRETL SSFKSEKTNS THLDSPPGGP APEGSDTDPP SEAELPASPD AGVPSDDTLR
   361  SFDTVIGAGT PPGLAEPLLV VRPKDLALLR PSKRQPPLRR HSPPGRAPRR PLLEGGGFFE
   421  DEDTSEGSEL SPASSLRSQR RYSTDSSSST SCYSPESSRG AAGGPRKRRA PHGAEEGTAV
   481  PPKRPYGTQR TPSTASAKTH ARVLSMDGAG GDVLRPPLAG CKAELEAQVG VEQAASEPVV
   541  LPAEARRGPA ANQPGWRGEL QEEGAVGGAA EETGRRDRSS SVRRTQAIRR RHNAGSNPTP
   601  PASVMGSPPS SLQEAQRGRA ASHSRALTLP SALHFASSLL LTRAGANVHE ACTFDDTSEG
   661  AVHYFYDESG VRRSYTFGLA GGGYENPVGQ QGEQTANGAW DRHSHSSSFH SADVPEATGG
   721  LNLLQPRPVV LQGMQVRRVP LEIPEEQTLM EEAPPRAQHS YKYWLLPGRW TSVRYERLAL
   781  LALLDRTRGV LENIFGVGLS SLVAFLGYLL LLKGFFTDIW VFQFCLVIAS CQYSLLKSVQ
   841  PDAASPMHGH NWVIAYSRPV YFCICCLLIW LLDALGSAQP FPPVSLYGLT LFSASFFFCA
   901  RDVATVFTLC FPFVFLLGLL PQVNTCLMYL LEQIDMHGFG GTAATSPLTA VFSLSRSLLA
   961  AALLYGFCLG AIKTPWPEQH VPVLFSVFCG LLVALSYHLS RQSSDPTVLW SLIRSKLFPE
  1021  LEERSLETAR AEPPDPLPDK MRQSVREVLH SDLVMCVVIA VLTFAISAST VFIALKSVLG
  1081  FVLYALAGAV GFFTHYLLPQ LRKQLPWFCL SQPVLKPLEY SQYEVRGAAQ VMWFEKLYAG
  1141  LQCVEKYLIY PAVVLNALTV DAHTVVSHPD KYCFYCRALL MTVAGLKLLR SAFCCPPQQY
  1201  LTLAFTVLLF HFDYPRLSQG FLLDYFLMSL LCSKLWDLLY KLRFVLTYIA PWQITWGSAF
  1261  HAFAQPFAVP HSAMLFVQAL LSGLFSTPLN PLLGSAVFIM SYARPLKFWE RDYNTKRVDH
  1321  SNTRLVTQLD RNPGADDNNL NSIFYEHLTR SLQHTLCGDL VLGRWGNYGP GDCFVLASDY
  1381  LNALVHLIEV GNGLVTFQLR GLEFRGTYCQ QREVEAITEG VEEDEGCCCC EPGHLPRVLS
  1441  FNAAFGQRWL AWEVTASKYV LEGYSISDNN AASMLQVFDL RKILITYYVK SIIYYVSRSP
  1501  KLEVWLSHEG ITAALRPVRV PGYADSDPTF SLSVDEDYDL RLSGLSLPSF CAVHLEWIQY
  1561  CASRRSQPVD QDWNSPLVTL CFGLCVLGRR ALGTASHSMS ASLEPFLYGL HALFKGDFRI
  1621  TSPRDEWVFA DMDLLHRVVA PGVRMALKLH QDHFTSPDEY EEPAALYDAI AANEERLVIS
  1681  HEGDPAWRSA ILSNTPSLLA LRHVLDDASD EYKIIMLNRR HLSFRVIKVN RECVRGLWAG
  1741  QQQELVFLRN RNPERGSIQN AKQALRNMIN SSCDQPLGYP IYVSPLTTSL AGSHPQLRAL
  1801  WGGPISLGAI AHWLLRTWER LHKGCGAGCN SGGNVDDSDC SGGGGLTSLS NNPPVAHPTP
  1861  ENTAGNGDQP LPPGPGWGPR SSLSGSGDGR PPPLLQWPPP RLPGPPPASP IPTEGPRTSR
  1921  PPGPGLLSSE GPSGKWSLGG RKGLGGSDGE PASGSPKGGT PKSQAPLDLS LSLSLSLSPD
  1981  VSTEASPPRA SQDIPCLDSS APESGTPMGA LGDWPAPIEE RESPAAQPLL EHQY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCNX3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 9.8 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 9.8 nTPM
small intestine: 8.5 nTPM
testis: 8.4 nTPM
cerebellum: 8 nTPM
spleen: 8 nTPM
duodenum: 7.7 nTPM

Single-cell type

adrenal medulla cells: 32 nCPM
colonocytes: 27 nCPM
endometrial glandular cells: 26 nCPM
foveolar cells: 24 nCPM
alveolar cells type 1: 24 nCPM
enterocytes: 22 nCPM

Immune cell

basophil: 3.5 nTPM
neutrophil: 1.3 nTPM
gdT-cell: 1.2 nTPM
plasmacytoid DC: 1.2 nTPM
MAIT T-cell: 1 nTPM
classical monocyte: 0.9 nTPM

Brain region

thalamus: 31 nTPM
white matter: 31 nTPM
cerebral cortex: 31 nTPM
medulla oblongata: 31 nTPM
amygdala: 30 nTPM
midbrain: 29 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PCNX3.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 62 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Moyamoya angiopathy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.23
gnomAD pLI: 1
DepMap mean gene effect: -0.43
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCNX3 as an antibody target. Whether an autoantibody or antibody against PCNX3 could matter depends on whether native PCNX3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCNX3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PCNX3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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