Seroatlas · Human Serome Atlas

PCNX1

Pecanex-like protein 1

Also known as: KIAA0805, KIAA0995, PCNX, PCNXL1, PCX1_HUMAN, pecanex

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96RV3
Gene: PCNX1
Ensembl: ENSG00000100731
Chromosome: 14
Canonical length: 2341 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes an evolutionarily conserved transmembrane protein similar to the pecanex protein in Drosophila. The fly protein is a component of the Notch signaling pathway, which functions in several developmental processes. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

2341 residues, UniProt reviewed canonical sequence.

>Q96RV3|PCNX1
     1  MGSQTLQILR QGVWAALSGG WYYDPHQATF VNALHLYLWL FLLGLPFTLY MALPSTMIIV
    61  AVYCPVIAAV FIVLKMVNYR LHRALDAGEV VDRTANEFTD QRTKAEQGNC STRRKDSNGP
   121  SDPGGGIEMS EFIREATPPV GCSSRNSYAG LDPSNQIGSG SSRLGTAATI KGDTDTAKTS
   181  DDISLSLGQS SSLCKEGSEE QDLAADRKLF RLVSNDSFIS IQPSLSSCGQ DLPRDFSDKV
   241  NLPSHNHHHH VDQSLSSACD TEVASLVPLH SHSYRKDHRP RGVPRTSSSA VAFPDTSLND
   301  FPLYQQRRGL DPVSELESSK PLSGSKESLV ENSGLSGEFQ LAGDLKINTS QPPTKSGKSK
   361  PLKAEKSMDS LRSLSTRSSG STESYCSGTD RDTNSTVSSY KSEQTSSTHI ESILSEHEES
   421  PKAGTKSGRK KECCAGPEEK NSCASDKRTS SEKIAMEAST NSGVHEAKDP TPSDEMHNQR
   481  GLSTSASEEA NKNPHANEFT SQGDRPPGNT AENKEEKSDK SAVSVDSKVR KDVGGKQKEG
   541  DVRPKSSSVI HRTASAHKSG RRRTGKKRAS SFDSSRHRDY VCFRGVSGTK PHSAIFCHDE
   601  DSSDQSDLSR ASSVQSAHQF SSDSSSSTTS HSCQSPEGRY SALKTKHTHK ERGTDSEHTH
   661  KAHLVPEGTS KKRATRRTSS TNSAKTRARV LSLDSGTVAC LNDSNRLMAP ESIKPLTTSK
   721  SDLEAKEGEV LDELSLLGRA SQLETVTRSR NSLPNQVAFP EGEEQDAVSG AAQASEEAVS
   781  FRRERSTFRR QAVRRRHNAG SNPTPPTLLI GSPLSLQDGQ QGQQSTAQVK VQSRPPSQAA
   841  VLSASASLLV RNGSVHLEAS HDNASAVGGS SLHDELGKFS STLYETGGCD MSLVNFEPAA
   901  RRASNICDTD SHVSSSTSVR FYPHDVLSLP QIRLNRLLTI DTDLLEQQDI DLSPDLAATY
   961  GPTEEAAQKV KHYYRFWILP QLWIGINFDR LTLLALFDRN REILENVLAV ILAILVAFLG
  1021  SILLIQGFFR DIWVFQFCLV IASCQYSLLK SVQPDSSSPR HGHNRIIAYS RPVYFCICCG
  1081  LIWLLDYGSR NLTATKFKLY GITFTNPLVF ISARDLVIVF TLCFPIVFFI GLLPQVNTFV
  1141  MYLCEQLDIH IFGGNATTSL LAALYSFICS IVAVALLYGL CYGALKDSWD GQHIPVLFSI
  1201  FCGLLVAVSY HLSRQSSDPS VLFSLVQSKI FPKTEEKNPE DPLSEVKDPL PEKLRNSVSE
  1261  RLQSDLVVCI VIGVLYFAIH VSTVFTVLQP ALKYVLYTLV GFVGFVTHYV LPQVRKQLPW
  1321  HCFSHPLLKT LEYNQYEVRN AATMMWFEKL HVWLLFVEKN IIYPLIVLNE LSSSAETIAS
  1381  PKKLNTELGA LMITVAGLKL LRSSFSSPTY QYVTVIFTVL FFKFDYEAFS ETMLLDLFFM
  1441  SILFNKLWEL LYKLQFVYTY IAPWQITWGS AFHAFAQPFA VPHSAMLFIQ AAVSAFFSTP
  1501  LNPFLGSAIF ITSYVRPVKF WERDYNTKRV DHSNTRLASQ LDRNPGSDDN NLNSIFYEHL
  1561  TRSLQHSLCG DLLLGRWGNY STGDCFILAS DYLNALVHLI EIGNGLVTFQ LRGLEFRGTY
  1621  CQQREVEAIT EGVEEDEGFC CCEPGHIPHM LSFNAAFSQR WLAWEVIVTK YILEGYSITD
  1681  NSAASMLQVF DLRKVLTTYY VKGIIYYVTT SSKLEEWLAN ETMQEGLRLC ADRNYVDVDP
  1741  TFNPNIDEDY DHRLAGISRE SFCVIYLNWI EYCSSRRAKP VDVDKDSSLV TLCYGLCVLG
  1801  RRALGTASHH MSSNLESFLY GLHALFKGDF RISSIRDEWI FADMELLRKV VVPGIRMSIK
  1861  LHQDHFTSPD EYDDPTVLYE AIVSHEKNLV IAHEGDPAWR SAVLANSPSL LALRHVMDDG
  1921  TNEYKIIMLN RRYLSFRVIK VNKECVRGLW AGQQQELVFL RNRNPERGSI QNAKQALRNM
  1981  INSSCDQPIG YPIFVSPLTT SYSDSHEQLK DILGGPISLG NIRNFIVSTW HRLRKGCGAG
  2041  CNSGGNIEDS DTGGGTSCTG NNATTANNPH SNVTQGSIGN PGQGSGTGLH PPVTSYPPTL
  2101  GTSHSSHSVQ SGLVRQSPAR ASVASQSSYC YSSRHSSLRM STTGFVPCRR SSTSQISLRN
  2161  LPSSIQSRLS MVNQMEPSGQ SGLACVQHGL PSSSSSSQSI PACKHHTLVG FLATEGGQSS
  2221  ATDAQPGNTL SPANNSHSRK AEVIYRVQIV DPSQILEGIN LSKRKELQWP DEGIRLKAGR
  2281  NSWKDWSPQE GMEGHVIHRW VPCSRDPGTR SHIDKAVLLV QIDDKYVTVI ETGVLELGAE
  2341  V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCNX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

tongue: 20 nTPM
testis: 19 nTPM
adrenal gland: 19 nTPM
bone marrow: 17 nTPM
thymus: 16 nTPM
retina: 15 nTPM

Single-cell type

neutrophils: 4,040 nCPM
neutrophil progenitors: 960 nCPM
adrenal cortex cells: 532 nCPM
t-cells: 529 nCPM
gonadotrophs: 490 nCPM
innate lymphoid cells: 468 nCPM

Immune cell

T-reg: 10 nTPM
neutrophil: 9.9 nTPM
memory CD4 T-cell: 5.9 nTPM
MAIT T-cell: 4.6 nTPM
naive CD8 T-cell: 4.1 nTPM
plasmacytoid DC: 3.7 nTPM

Brain region

choroid plexus: 42 nTPM
basal ganglia: 40 nTPM
cerebral cortex: 39 nTPM
hippocampal formation: 38 nTPM
hypothalamus: 37 nTPM
white matter: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.23
gnomAD pLI: 1
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCNX1 as an antibody target. Whether an autoantibody or antibody against PCNX1 could matter depends on whether native PCNX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCNX1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PCNX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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