Seroatlas · Human Serome Atlas

PCNP

PEST proteolytic signal-containing nuclear protein

Also known as: PCNP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WW12
Gene: PCNP
Ensembl: ENSG00000081154
Chromosome: 3
Canonical length: 178 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Located in nuclear body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

178 residues, UniProt reviewed canonical sequence.

>Q8WW12|PCNP
     1  MADGKAGDEK PEKSQRAGAA GGPEEEAEKP VKTKTVSSSN GGESSSRSAE KRSAEEEAAD
    61  LPTKPTKISK FGFAIGSQTT KKASAISIKL GSSKPKETVP TLAPKTLSVA AAFNEDEDSE
   121  PEEMPPEAKM RMKNIGRDTP TSAGPNSFNK GKHGFSDNQK LWERNIKSHL GNVHDQDN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCNP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 63 nTPM

Expression across tissuesHPA

Tissue

ovary: 63 nTPM
skeletal muscle: 62 nTPM
tongue: 62 nTPM
blood vessel: 59 nTPM
bone marrow: 55 nTPM
hypothalamus: 55 nTPM

Single-cell type

syncytiotrophoblasts: 306 nCPM
megakaryocytes: 297 nCPM
platelets: 292 nCPM
extravillous trophoblasts: 273 nCPM
esophageal apical cells: 269 nCPM
esophageal suprabasal cells: 214 nCPM

Immune cell

basophil: 59 nTPM
total PBMC: 41 nTPM
eosinophil: 39 nTPM
NK-cell: 37 nTPM
non-classical monocyte: 36 nTPM
T-reg: 36 nTPM

Brain region

choroid plexus: 61 nTPM
white matter: 56 nTPM
hypothalamus: 52 nTPM
cerebellum: 49 nTPM
cerebral cortex: 42 nTPM
spinal cord: 42 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PCNP.

Disease | ImmuneIEDB

Conditions an epitope on PCNP was assayed in.

brain glioma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0.79
gnomAD missense Z: 1.17
DepMap mean gene effect: -0.25
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

PEST proteolytic signal-containing nuclear protein
PEST, proteolytic signal-containing nuclear protein family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PCNP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

UHRF2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCNP as an antibody target. Whether an autoantibody or antibody against PCNP could matter depends on whether native PCNP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCNP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PCNP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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