Seroatlas · Human Serome Atlas

PCMTD2

Protein-L-isoaspartate O-methyltransferase domain-containing protein 2

Also known as: C20orf36, FLJ10883, PCMD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NV79
Gene: PCMTD2
Ensembl: ENSG00000203880
Chromosome: 20
Canonical length: 361 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Predicted to enable protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. Predicted to be involved in protein modification process. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

361 residues, UniProt reviewed canonical sequence.

>Q9NV79|PCMTD2
     1  MGGAVSAGED NDELIDNLKE AQYIRTELVE QAFRAIDRAD YYLEEFKENA YKDLAWKHGN
    61  IHLSAPCIYS EVMEALDLQP GLSFLNLGSG TGYLSSMVGL ILGPFGVNHG VELHSDVIEY
   121  AKQKLDFFIR TSDSFDKFDF CEPSFVTGNC LEISPDCSQY DRVYCGAGVQ KEHEEYMKNL
   181  LKVGGILVMP LEEKLTKITR TGPSAWETKK ILAVSFAPLI QPCHSESGKS RLVQLPPVAV
   241  RSLQDLARIA IRGTIKKIIH QETVSKNGNG LKNTPRFKRR RVRRRRMETI VFLDKEVFAS
   301  RISNPSDDNS CEDLEEERRE EEEKTPPETK PDPPVNFLRQ KVLSLPLPDP LKYYLLYYRE
   361  K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCMTD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 165 nTPM

Expression across tissuesHPA

Tissue

retina: 165 nTPM
skin: 61 nTPM
cerebellum: 52 nTPM
ovary: 48 nTPM
epididymis: 46 nTPM
skeletal muscle: 40 nTPM

Single-cell type

podocytes: 186 nCPM
oligodendrocyte progenitor cells: 168 nCPM
retinal pigment epithelial cells: 128 nCPM
renal collecting duct intercalated cells: 83 nCPM
rod photoreceptor cells: 77 nCPM
oligodendrocytes: 75 nCPM

Immune cell

T-reg: 20 nTPM
naive CD4 T-cell: 17 nTPM
NK-cell: 16 nTPM
memory CD4 T-cell: 12 nTPM
naive CD8 T-cell: 12 nTPM
basophil: 10 nTPM

Brain region

cerebellum: 73 nTPM
white matter: 68 nTPM
cerebral cortex: 55 nTPM
hypothalamus: 55 nTPM
basal ganglia: 54 nTPM
choroid plexus: 50 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0.01
gnomAD missense Z: 1.52
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

protein-L-isoaspartate (D-aspartate) O-methyltransferase activity

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCMTD2 as an antibody target. Whether an autoantibody or antibody against PCMTD2 could matter depends on whether native PCMTD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCMTD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PCMTD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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